CYBA [The Human Chemical-Genetic Interaction Map Project]

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======= CYBA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYBA
  * **<color #00a2e8>Official Name</color>**: cytochrome b-245 alpha chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1535|1535]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13498|P13498]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYBA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYBA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608508|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269|PubMed:15824103}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cytochrom B558a|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|smooth muscle hypertrophy|
|negative regulation of glomerular filtration by angiotensin|
|negative regulation of renal output by angiotensin|
|regulation of renal output by angiotensin|
|cellular response to L-glutamine|
|response to L-glutamine|
|negative regulation of glomerular filtration|
|smooth muscle adaptation|
|response to aldosterone|
|positive regulation of toll-like receptor 2 signaling pathway|
|positive regulation of mucus secretion|
|positive regulation of NAD(P)H oxidase activity|
|regulation of blood volume by renin-angiotensin|
|hydrogen peroxide biosynthetic process|
|regulation of mucus secretion|
|regulation of toll-like receptor 2 signaling pathway|
|positive regulation of defense response to bacterium|
|regulation of glomerular filtration|
|regulation of NAD(P)H oxidase activity|
|antibiotic biosynthetic process|
|superoxide-generating NADPH oxidase activity|
|positive regulation of systemic arterial blood pressure|
|NADPH oxidase complex|
|superoxide anion generation|
|renal system process involved in regulation of blood volume|
|perinuclear endoplasmic reticulum|
|regulation of defense response to bacterium|
|positive regulation of superoxide anion generation|
|respiratory burst|
|cellular response to angiotensin|
|regulation of superoxide anion generation|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|positive regulation of toll-like receptor signaling pathway|
|renal system process involved in regulation of systemic arterial blood pressure|
|reactive oxygen species biosynthetic process|
|response to angiotensin|
|cellular response to gamma radiation|
|muscle hypertrophy|
|muscle adaptation|
|response to mineralocorticoid|
|regulation of superoxide metabolic process|
|cytochrome complex assembly|
|regulation of renal system process|
|positive regulation of blood pressure|
|regulation of systemic arterial blood pressure by hormone|
|hydrogen peroxide metabolic process|
|superoxide metabolic process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of oxidoreductase activity|
|response to gamma radiation|
|response to activity|
|cellular response to nutrient|
|vascular endothelial growth factor receptor signaling pathway|
|positive regulation of phagocytosis|
|regulation of toll-like receptor signaling pathway|
|stress fiber|
|cellular response to glucose stimulus|
|cellular response to ionizing radiation|
|cellular response to amino acid stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|phagocytic vesicle membrane|
|tertiary granule membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|electron transfer activity|
|cell redox homeostasis|
|regulation of release of sequestered calcium ion into cytosol|
|cellular response to mechanical stimulus|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|cellular response to carbohydrate stimulus|
|positive regulation of tumor necrosis factor production|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of smooth muscle cell proliferation|
|secretory granule|
|cellular glucose homeostasis|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|specific granule membrane|
|regulation of systemic arterial blood pressure|
|positive regulation of endothelial cell proliferation|
|positive regulation of interleukin-6 production|
|regulation of phagocytosis|
|regulation of oxidoreductase activity|
|positive regulation of reactive oxygen species metabolic process|
|antigen processing and presentation of peptide antigen via MHC class I|
|regulation of calcium ion transport into cytosol|
|antibiotic metabolic process|
|renal system process|
|reactive oxygen species metabolic process|
|response to amino acid|
|regulation of sequestering of calcium ion|
|regulation of endothelial cell proliferation|
|SH3 domain binding|
|regulation of smooth muscle cell proliferation|
|response to glucose|
|regulation of interleukin-6 production|
|heme binding|
|response to hexose|
|regulation of calcium ion transmembrane transport|
|response to monosaccharide|
|regulation of tumor necrosis factor production|
|response to ionizing radiation|
|regulation of tumor necrosis factor superfamily cytokine production|
|response to corticosteroid|
|positive regulation of cell growth|
|response to carbohydrate|
|cellular response to radiation|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of reactive oxygen species metabolic process|
|electron transport chain|
|regulation of blood pressure|
|antigen processing and presentation of exogenous antigen|
|glucose homeostasis|
|carbohydrate homeostasis|
|positive regulation of epithelial cell proliferation|
|antigen processing and presentation of peptide antigen|
|response to ketone|
|response to interleukin-1|
|cellular response to acid chemical|
|cofactor biosynthetic process|
|response to mechanical stimulus|
|response to nutrient|
|antigen processing and presentation|
|response to alcohol|
|cellular response to nutrient levels|
|cellular response to tumor necrosis factor|
|cellular response to oxidative stress|
|regulation of calcium ion transport|
|positive regulation of growth|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|endosome|
|muscle system process|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|apical plasma membrane|
|cellular response to peptide|
|response to steroid hormone|
|regulation of cation transmembrane transport|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|positive regulation of innate immune response|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|positive regulation of response to biotic stimulus|
|neuronal cell body|
|response to oxygen levels|
|response to oxidative stress|
|regulation of metal ion transport|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|cellular response to drug|
|focal adhesion|
|regulation of cell growth|
|dendrite|
|generation of precursor metabolites and energy|
|positive regulation of secretion|
|cofactor metabolic process|
|response to radiation|
|positive regulation of cytokine production|
|regulation of innate immune response|
|response to peptide|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|response to nutrient levels|
|inflammatory response|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|regulation of system process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|regulation of growth|
|regulation of cytokine production|
|regulation of ion transport|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|cellular chemical homeostasis|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|cellular protein-containing complex assembly|
|response to lipid|
|positive regulation of immune response|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|leukocyte activation|
|endoplasmic reticulum membrane|
|defense response to other organism|
|oxidation-reduction process|
|Golgi apparatus|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4235
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYBA Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>