CYGB [The Human Chemical-Genetic Interaction Map Project]

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======= CYGB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYGB
  * **<color #00a2e8>Official Name</color>**: cytoglobin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114757|114757]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WWM9|Q8WWM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYGB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYGB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608759|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Globin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fatty acid peroxidase activity|
|negative regulation of hepatic stellate cell activation|
|catalase activity|
|regulation of hepatic stellate cell activation|
|negative regulation of fibroblast migration|
|negative regulation of collagen biosynthetic process|
|negative regulation of collagen metabolic process|
|oxygen carrier activity|
|oxygen transport|
|gas transport|
|regulation of fibroblast migration|
|oxygen binding|
|peroxidase activity|
|regulation of collagen biosynthetic process|
|regulation of collagen metabolic process|
|regulation of nitric-oxide synthase activity|
|regulation of monooxygenase activity|
|fatty acid oxidation|
|lipid oxidation|
|cellular oxidant detoxification|
|regulation of oxidoreductase activity|
|cellular detoxification|
|detoxification|
|iron ion binding|
|heme binding|
|drug transport|
|negative regulation of cell activation|
|lipid modification|
|cellular response to toxic substance|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|neuron projection|
|negative regulation of locomotion|
|fatty acid metabolic process|
|response to hypoxia|
|response to decreased oxygen levels|
|neuronal cell body|
|response to oxygen levels|
|response to oxidative stress|
|nuclear speck|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|regulation of cell activation|
|regulation of cell migration|
|carboxylic acid metabolic process|
|regulation of cell motility|
|cellular lipid metabolic process|
|oxidation-reduction process|
|regulation of locomotion|
|regulation of cellular component movement|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|response to abiotic stimulus|
|lipid metabolic process|
|negative regulation of biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6710
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYGB Expression in NALM6 Cells: 1.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>