CYP21A2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CYP21A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP21A2
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 21 subfamily A member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1589|1589]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08686|P08686]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP21A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP21A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613815|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|steroid 21-monooxygenase activity|
|mineralocorticoid biosynthetic process|
|mineralocorticoid metabolic process|
|glucocorticoid biosynthetic process|
|glucocorticoid metabolic process|
|steroid binding|
|steroid hydroxylase activity|
|steroid hormone biosynthetic process|
|hormone biosynthetic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|iron ion binding|
|sterol metabolic process|
|heme binding|
|hormone metabolic process|
|steroid metabolic process|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16453
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP21A2 Expression in NALM6 Cells: -0.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>