DAD1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAD1
  * **<color #00a2e8>Official Name</color>**: defender against cell death 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1603|1603]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61803|P61803]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600243|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. Loss of the DAD1 protein triggers apoptosis. {ECO:0000269|PubMed:22467853, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oligosaccharyl transferase activity|
|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|
|oligosaccharyltransferase complex|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|protein N-linked glycosylation|
|blastocyst development|
|response to nutrient|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|in utero embryonic development|
|glycoprotein metabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|carbohydrate derivative biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|endoplasmic reticulum membrane|
|embryo development|
|negative regulation of cell death|
|response to drug|
|carbohydrate derivative metabolic process|
|programmed cell death|
|cell death|
|organonitrogen compound biosynthetic process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.36|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.71|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.7|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.8|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.85|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.87|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.91|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.17|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.26|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.607|
|[[:human genes:d:dpagt1|DPAGT1]]|0.602|
|[[:human genes:r:rpn1|RPN1]]|0.593|
|[[:human genes:h:hars|HARS]]|0.583|
|[[:human genes:r:rnmt|RNMT]]|0.568|
|[[:human genes:g:gmppb|GMPPB]]|0.565|
|[[:human genes:t:tti2|TTI2]]|0.554|
|[[:human genes:g:gfpt1|GFPT1]]|0.551|
|[[:human genes:a:alg1|ALG1]]|0.546|
|[[:human genes:t:triap1|TRIAP1]]|0.531|
|[[:human genes:d:ddost|DDOST]]|0.53|
|[[:human genes:t:thg1l|THG1L]]|0.529|
|[[:human genes:o:oraov1|ORAOV1]]|0.527|
|[[:human genes:s:srp14|SRP14]]|0.521|
|[[:human genes:p:pam16|PAM16]]|0.52|
|[[:human genes:p:pelo|PELO]]|0.519|
|[[:human genes:p:polr3h|POLR3H]]|0.517|
|[[:human genes:h:hspd1|HSPD1]]|0.516|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.51|
|[[:human genes:g:gnb1l|GNB1L]]|0.51|
|[[:human genes:m:meaf6|MEAF6]]|0.51|
|[[:human genes:r:rptor|RPTOR]]|0.508|
|[[:human genes:m:med16|MED16]]|0.506|
|[[:human genes:a:alg5|ALG5]]|0.5|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.494|
|[[:human genes:t:tti1|TTI1]]|0.482|
|[[:human genes:a:alg13|ALG13]]|0.481|
|[[:human genes:t:telo2|TELO2]]|0.481|
|[[:human genes:u:uap1|UAP1]]|0.479|
|[[:human genes:m:mtor|MTOR]]|0.479|
|[[:human genes:a:alg2|ALG2]]|0.477|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.474|
|[[:human genes:e:eprs|EPRS]]|0.472|
|[[:human genes:e:eny2|ENY2]]|0.468|
|[[:human genes:z:znf259|ZNF259]]|0.467|
|[[:human genes:s:spcs2|SPCS2]]|0.467|
|[[:human genes:r:rtcb|RTCB]]|0.465|
|[[:human genes:s:srprb|SRPRB]]|0.464|
|[[:human genes:b:bap1|BAP1]]|0.461|
|[[:human genes:t:tsen54|TSEN54]]|0.454|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.453|
|[[:human genes:r:romo1|ROMO1]]|0.452|
|[[:human genes:m:max|MAX]]|0.452|
|[[:human genes:a:aars|AARS]]|0.451|
|[[:human genes:e:eif4e|EIF4E]]|0.45|
|[[:human genes:c:cbfb|CBFB]]|0.45|
|[[:human genes:a:alg14|ALG14]]|0.45|
|[[:human genes:p:polr3b|POLR3B]]|0.45|
|[[:human genes:w:wdr24|WDR24]]|0.45|
|[[:human genes:s:spcs3|SPCS3]]|0.449|
|[[:human genes:c:crcp|CRCP]]|0.449|
|[[:human genes:s:srp68|SRP68]]|0.449|
|[[:human genes:s:srp72|SRP72]]|0.448|
|[[:human genes:d:dhdds|DHDDS]]|0.448|
|[[:human genes:t:trmt5|TRMT5]]|0.447|
|[[:human genes:s:slc35b1|SLC35B1]]|0.447|
|[[:human genes:u:ube2g2|UBE2G2]]|0.446|
|[[:human genes:a:adsl|ADSL]]|0.444|
|[[:human genes:r:rpp21|RPP21]]|0.443|
|[[:human genes:n:nars|NARS]]|0.442|
|[[:human genes:u:ube2j1|UBE2J1]]|0.441|
|[[:human genes:t:thoc6|THOC6]]|0.441|
|[[:human genes:u:utp23|UTP23]]|0.439|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.435|
|[[:human genes:a:atxn10|ATXN10]]|0.435|
|[[:human genes:c:csnk2b|CSNK2B]]|0.434|
|[[:human genes:s:sec61g|SEC61G]]|0.434|
|[[:human genes:d:ddx20|DDX20]]|0.433|
|[[:human genes:n:nae1|NAE1]]|0.433|
|[[:human genes:g:gemin5|GEMIN5]]|0.432|
|[[:human genes:c:ccdc101|CCDC101]]|0.43|
|[[:human genes:e:exoc4|EXOC4]]|0.43|
|[[:human genes:e:exoc3|EXOC3]]|0.429|
|[[:human genes:n:nsmce1|NSMCE1]]|0.429|
|[[:human genes:t:tbca|TBCA]]|0.428|
|[[:human genes:c:cdipt|CDIPT]]|0.428|
|[[:human genes:r:rpn2|RPN2]]|0.427|
|[[:human genes:r:rad1|RAD1]]|0.426|
|[[:human genes:s:sec63|SEC63]]|0.426|
|[[:human genes:o:osgep|OSGEP]]|0.426|
|[[:human genes:d:dohh|DOHH]]|0.424|
|[[:human genes:a:alg6|ALG6]]|0.424|
|[[:human genes:h:hccs|HCCS]]|0.423|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.422|
|[[:human genes:t:timm13|TIMM13]]|0.421|
|[[:human genes:d:dhps|DHPS]]|0.416|
|[[:human genes:c:crls1|CRLS1]]|0.415|
|[[:human genes:a:abcb7|ABCB7]]|0.414|
|[[:human genes:s:stt3a|STT3A]]|0.414|
|[[:human genes:c:casp9|CASP9]]|0.414|
|[[:human genes:m:mars|MARS]]|0.414|
|[[:human genes:t:trnt1|TRNT1]]|0.413|
|[[:human genes:a:apaf1|APAF1]]|0.411|
|[[:human genes:z:zbtb11|ZBTB11]]|0.41|
|[[:human genes:f:faf2|FAF2]]|0.409|
|[[:human genes:p:plaa|PLAA]]|0.408|
|[[:human genes:t:taz|TAZ]]|0.408|
|[[:human genes:a:atp2a2|ATP2A2]]|0.406|
|[[:human genes:a:atp5j|ATP5J]]|0.405|
|[[:human genes:r:rpe|RPE]]|0.405|
|[[:human genes:d:dnajc3|DNAJC3]]|0.404|
|[[:human genes:a:actr10|ACTR10]]|0.403|
|[[:human genes:d:derl2|DERL2]]|0.403|
|[[:human genes:t:tgs1|TGS1]]|0.401|
|[[:human genes:c:cep350|CEP350]]|0.401|
|[[:human genes:u:uxt|UXT]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 725/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|31/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 742
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAD1 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>