DBH [The Human Chemical-Genetic Interaction Map Project]

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======= DBH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DBH
  * **<color #00a2e8>Official Name</color>**: dopamine beta-hydroxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1621|1621]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09172|P09172]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DBH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DBH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609312|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Conversion of dopamine to noradrenaline. {ECO:0000269|PubMed:27148966, ECO:0000269|PubMed:3443096, ECO:0000269|PubMed:7961964, ECO:0000269|PubMed:8546710}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DOMON|
|Cu2 monooxygen|
|Cu2 monoox C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromaffin granule lumen|
|homoiothermy|
|octopamine biosynthetic process|
|dopamine beta-monooxygenase activity|
|octopamine metabolic process|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen|
|chromaffin granule membrane|
|norepinephrine biosynthetic process|
|ethanolamine-containing compound metabolic process|
|dopamine catabolic process|
|catechol-containing compound catabolic process|
|catecholamine catabolic process|
|behavioral response to ethanol|
|phenol-containing compound catabolic process|
|norepinephrine metabolic process|
|parental behavior|
|maternal behavior|
|catechol-containing compound biosynthetic process|
|catecholamine biosynthetic process|
|L-ascorbic acid binding|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|dopamine metabolic process|
|reproductive behavior|
|temperature homeostasis|
|response to pain|
|positive regulation of vasoconstriction|
|response to amphetamine|
|blood vessel remodeling|
|fear response|
|phenol-containing compound biosynthetic process|
|transport vesicle membrane|
|neurotransmitter biosynthetic process|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|catalytic activity|
|response to amine|
|visual learning|
|response to bronchodilator|
|visual behavior|
|copper ion binding|
|cellular biogenic amine metabolic process|
|regulation of vasoconstriction|
|cellular amine metabolic process|
|amine metabolic process|
|multicellular organismal response to stress|
|positive regulation of blood circulation|
|organic hydroxy compound catabolic process|
|associative learning|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|secretory granule membrane|
|positive regulation of cold-induced thermogenesis|
|tissue remodeling|
|alcohol biosynthetic process|
|secretory granule lumen|
|memory|
|response to ethanol|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|regulation of cold-induced thermogenesis|
|adult behavior|
|drug catabolic process|
|learning|
|cytokine production|
|regulation of extrinsic apoptotic signaling pathway|
|microtubule organizing center|
|vascular process in circulatory system|
|glucose homeostasis|
|organic hydroxy compound biosynthetic process|
|carbohydrate homeostasis|
|ammonium ion metabolic process|
|locomotory behavior|
|response to alcohol|
|learning or memory|
|regulation of blood circulation|
|cognition|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to light stimulus|
|alcohol metabolic process|
|multicellular organismal homeostasis|
|regulation of neurotransmitter levels|
|leukocyte migration|
|blood circulation|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|response to radiation|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|organic cyclic compound catabolic process|
|drug metabolic process|
|response to toxic substance|
|regulation of anatomical structure size|
|behavior|
|regulation of system process|
|small molecule biosynthetic process|
|intracellular membrane-bounded organelle|
|leukocyte mediated immunity|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|cell migration|
|oxidation-reduction process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|immune effector process|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|nervous system process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.15|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-2.08|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.9|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.89|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.84|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.76|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.77|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.81|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.86|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.89|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.9|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9498
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DBH Expression in NALM6 Cells: 1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>