DCAF7 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DCAF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCAF7
  * **<color #00a2e8>Official Name</color>**: DDB1 and CUL4 associated factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10238|10238]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61962|P61962]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCAF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCAF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605973|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250, ECO:0000269|PubMed:16887337, ECO:0000269|PubMed:16949367}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul4-RING E3 ubiquitin ligase complex|
|nuclear matrix|
|nuclear body|
|post-translational protein modification|
|protein-containing complex|
|protein ubiquitination|
|protein modification by small protein conjugation|
|protein modification by small protein conjugation or removal|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.78|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.37|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.29|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.08|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.89|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.83|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.77|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.76|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.75|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.78|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.78|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.85|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.87|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.99|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.08|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.21|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.27|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.39|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:max|MAX]]|0.473|
|[[:human genes:m:med13l|MED13L]]|0.469|
|[[:human genes:b:brpf1|BRPF1]]|0.433|
|[[:human genes:m:med13|MED13]]|0.433|
|[[:human genes:m:mllt1|MLLT1]]|0.428|
|[[:human genes:t:tada3|TADA3]]|0.418|
|[[:human genes:f:fli1|FLI1]]|0.409|
|[[:human genes:m:med23|MED23]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 514
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCAF7 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>