DCLRE1C [The Human Chemical-Genetic Interaction Map Project]

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======= DCLRE1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCLRE1C
  * **<color #00a2e8>Official Name</color>**: DNA cross-link repair 1C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64421|64421]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96SD1|Q96SD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCLRE1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCLRE1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605988|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lactamase B 2|
|DRMBL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5-3 exodeoxyribonuclease activity|
|protection from non-homologous end joining at telomere|
|nonhomologous end joining complex|
|single-stranded DNA endodeoxyribonuclease activity|
|telomere maintenance in response to DNA damage|
|5-3 exonuclease activity|
|V(D)J recombination|
|telomere capping|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|endonuclease activity|
|somatic diversification of immune receptors|
|interstrand cross-link repair|
|damaged DNA binding|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|telomere maintenance|
|telomere organization|
|B cell differentiation|
|nuclear chromosome, telomeric region|
|response to ionizing radiation|
|B cell activation|
|double-strand break repair|
|DNA recombination|
|lymphocyte differentiation|
|nucleic acid phosphodiester bond hydrolysis|
|leukocyte differentiation|
|anatomical structure homeostasis|
|lymphocyte activation|
|response to radiation|
|DNA repair|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|immune system development|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|leukocyte activation|
|Golgi apparatus|
|chromosome organization|
|cell activation|
|response to abiotic stimulus|
|homeostatic process|
|cellular response to stress|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.84|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.67|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.21|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8862
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCLRE1C Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>