DCN [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DCN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCN
  * **<color #00a2e8>Official Name</color>**: decorin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1634|1634]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07585|P07585]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125255|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May affect the rate of fibrils formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|LRRNT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|collagen type VI trimer|
|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|
|negative regulation of vascular endothelial growth factor signaling pathway|
|negative regulation of cellular response to vascular endothelial growth factor stimulus|
|positive regulation of mitochondrial depolarization|
|dermatan sulfate biosynthetic process|
|positive regulation of membrane depolarization|
|dermatan sulfate metabolic process|
|chondroitin sulfate catabolic process|
|positive regulation of mitochondrial fission|
|dermatan sulfate proteoglycan biosynthetic process|
|extracellular matrix structural constituent conferring compression resistance|
|dermatan sulfate proteoglycan metabolic process|
|regulation of vascular endothelial growth factor signaling pathway|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|regulation of mitochondrial depolarization|
|regulation of mitochondrial fission|
|glycosaminoglycan binding|
|chondroitin sulfate biosynthetic process|
|extracellular matrix binding|
|chondroitin sulfate proteoglycan biosynthetic process|
|chondroitin sulfate metabolic process|
|regulation of membrane depolarization|
|chondroitin sulfate proteoglycan metabolic process|
|negative regulation of endothelial cell migration|
|sulfur compound catabolic process|
|peptide cross-linking|
|glycosaminoglycan catabolic process|
|collagen binding|
|negative regulation of epithelial cell migration|
|aminoglycan catabolic process|
|proteoglycan biosynthetic process|
|positive regulation of macroautophagy|
|regulation of mitochondrial membrane potential|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|proteoglycan metabolic process|
|lysosomal lumen|
|Golgi lumen|
|negative regulation of angiogenesis|
|glycosaminoglycan biosynthetic process|
|negative regulation of blood vessel morphogenesis|
|mucopolysaccharide metabolic process|
|protein N-terminus binding|
|aminoglycan biosynthetic process|
|positive regulation of mitochondrion organization|
|negative regulation of vasculature development|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of autophagy|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|negative regulation of cellular response to growth factor stimulus|
|placenta development|
|glycosaminoglycan metabolic process|
|regulation of endothelial cell migration|
|aminoglycan metabolic process|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|carbohydrate derivative catabolic process|
|peptidyl-serine modification|
|response to mechanical stimulus|
|regulation of epithelial cell migration|
|negative regulation of cell migration|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|aging|
|striated muscle tissue development|
|renal system development|
|regulation of angiogenesis|
|muscle organ development|
|muscle tissue development|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of locomotion|
|glycoprotein biosynthetic process|
|response to molecule of bacterial origin|
|regulation of autophagy|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|positive regulation of cellular catabolic process|
|sulfur compound metabolic process|
|extracellular structure organization|
|glycoprotein metabolic process|
|reproductive structure development|
|reproductive system development|
|regulation of membrane potential|
|positive regulation of catabolic process|
|muscle structure development|
|wound healing|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|response to wounding|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|positive regulation of organelle organization|
|developmental process involved in reproduction|
|response to bacterium|
|ion homeostasis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|peptidyl-amino acid modification|
|carboxylic acid metabolic process|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of locomotion|
|regulation of catabolic process|
|regulation of cellular component movement|
|oxoacid metabolic process|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.92|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.87|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.85|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13818
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCN Expression in NALM6 Cells: 1.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>