DCTN3 [The Human Chemical-Genetic Interaction Map Project]

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======= DCTN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCTN3
  * **<color #00a2e8>Official Name</color>**: dynactin subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11258|11258]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75935|O75935]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCTN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCTN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607387|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000269|PubMed:9722614}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynactin p22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dynactin complex|
|cleavage furrow|
|condensed chromosome kinetochore|
|ciliary basal body-plasma membrane docking|
|cytoskeleton-dependent cytokinesis|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|cytokinesis|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|spindle|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|midbody|
|organelle localization by membrane tethering|
|antigen processing and presentation of exogenous peptide antigen|
|membrane docking|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|structural molecule activity|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|microtubule|
|cilium assembly|
|cilium organization|
|Golgi vesicle transport|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|centrosome|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|regulation of cell cycle process|
|organelle assembly|
|nucleolus|
|cell cycle process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|cell cycle|
|intracellular transport|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.96|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.9|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 182/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|5/26|
|breast|12/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|5/21|
|liver|6/20|
|lung|24/75|
|lymphocyte|4/16|
|ovary|6/26|
|pancreas|6/24|
|peripheral nervous system|6/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|8/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1441
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCTN3 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>