DCXR [The Human Chemical-Genetic Interaction Map Project]

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======= DCXR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DCXR
  * **<color #00a2e8>Official Name</color>**: dicarbonyl and L-xylulose reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51181|51181]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z4W1|Q7Z4W1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DCXR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DCXR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608347|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KR|
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-xylulose reductase (NAD+) activity|
|L-xylulose reductase (NADP+) activity|
|D-xylose metabolic process|
|xylulose metabolic process|
|glucuronate catabolic process|
|xylulose 5-phosphate metabolic process|
|carbonyl reductase (NADPH) activity|
|glucuronate catabolic process to xylulose 5-phosphate|
|xylulose 5-phosphate biosynthetic process|
|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|
|pentose metabolic process|
|uronic acid metabolic process|
|glucuronate metabolic process|
|NADP metabolic process|
|brush border|
|cytoplasmic microtubule|
|monosaccharide catabolic process|
|microvillus|
|protein homotetramerization|
|glucose metabolic process|
|monocarboxylic acid catabolic process|
|carbohydrate catabolic process|
|protein tetramerization|
|hexose metabolic process|
|monosaccharide metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|protein homooligomerization|
|small molecule catabolic process|
|carbohydrate metabolic process|
|protein complex oligomerization|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|protein-containing complex assembly|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14829
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DCXR Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>