DDAH1 [The Human Chemical-Genetic Interaction Map Project]

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======= DDAH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDAH1
  * **<color #00a2e8>Official Name</color>**: dimethylarginine dimethylaminohydrolase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23576|23576]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94760|O94760]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDAH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDAH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604743|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Amidinotransf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dimethylargininase activity|
|negative regulation of cellular response to hypoxia|
|citrulline metabolic process|
|arginine catabolic process|
|negative regulation of vascular permeability|
|regulation of cellular response to hypoxia|
|arginine metabolic process|
|amino acid binding|
|nitric oxide mediated signal transduction|
|glutamine family amino acid catabolic process|
|regulation of vascular permeability|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|regulation of nitric-oxide synthase activity|
|catalytic activity|
|positive regulation of reactive oxygen species biosynthetic process|
|regulation of monooxygenase activity|
|regulation of nitric oxide biosynthetic process|
|glutamine family amino acid metabolic process|
|regulation of reactive oxygen species biosynthetic process|
|regulation of systemic arterial blood pressure|
|positive regulation of reactive oxygen species metabolic process|
|regulation of oxidoreductase activity|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|positive regulation of angiogenesis|
|vascular process in circulatory system|
|regulation of reactive oxygen species metabolic process|
|regulation of blood pressure|
|positive regulation of vasculature development|
|alpha-amino acid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|regulation of angiogenesis|
|cellular amino acid metabolic process|
|regulation of vasculature development|
|second-messenger-mediated signaling|
|regulation of neurotransmitter levels|
|blood circulation|
|circulatory system process|
|small molecule catabolic process|
|negative regulation of cell population proliferation|
|regulation of cellular response to stress|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|positive regulation of developmental process|
|regulation of response to stress|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.78|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8088
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDAH1 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>