DDRGK1 [The Human Chemical-Genetic Interaction Map Project]

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======= DDRGK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDRGK1
  * **<color #00a2e8>Official Name</color>**: DDRGK domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65992|65992]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HY6|Q96HY6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDRGK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDRGK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616177|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DDRGK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|positive regulation of protein localization to endoplasmic reticulum|
|regulation of protein localization to endoplasmic reticulum|
|protein K69-linked ufmylation|
|protein polyufmylation|
|positive regulation of I-kappaB phosphorylation|
|regulation of I-kappaB phosphorylation|
|protein ufmylation|
|positive regulation of metallopeptidase activity|
|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of metallopeptidase activity|
|ubiquitin-like protein ligase binding|
|positive regulation of transcription regulatory region DNA binding|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|RNA polymerase II repressing transcription factor binding|
|regulation of intracellular estrogen receptor signaling pathway|
|positive regulation of cell cycle G1/S phase transition|
|negative regulation of ubiquitin-dependent protein catabolic process|
|regulation of transcription regulatory region DNA binding|
|positive regulation of DNA binding|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of cellular protein catabolic process|
|positive regulation of cell cycle phase transition|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of DNA binding|
|negative regulation of protein catabolic process|
|positive regulation of cellular protein catabolic process|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of cell cycle G1/S phase transition|
|cartilage development|
|positive regulation of binding|
|regulation of proteasomal protein catabolic process|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of peptidase activity|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|connective tissue development|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|response to endoplasmic reticulum stress|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of cell cycle process|
|negative regulation of catabolic process|
|positive regulation of cellular protein localization|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|skeletal system development|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of locomotion|
|regulation of proteolysis|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|regulation of cell migration|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cell death|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.42|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.3|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.87|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.86|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.8|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.76|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.71|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.8|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.88|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c1orf27|C1orf27]]|0.596|
|[[:human genes:u:uba5|UBA5]]|0.587|
|[[:human genes:u:ufsp2|UFSP2]]|0.579|
|[[:human genes:u:ufc1|UFC1]]|0.532|
|[[:human genes:u:ufm1|UFM1]]|0.527|
|[[:human genes:u:ufl1|UFL1]]|0.512|
|[[:human genes:u:ube2j1|UBE2J1]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7384
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDRGK1 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>