DDX20 [The Human Chemical-Genetic Interaction Map Project]

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======= DDX20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX20
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11218|11218]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHI6|Q9UHI6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606168|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II transcription repressor complex|
|SMN complex|
|Gemini of coiled bodies|
|spliceosomal tri-snRNP complex assembly|
|SMN-Sm protein complex|
|spliceosomal snRNP assembly|
|repressing transcription factor binding|
|RNA helicase activity|
|oogenesis|
|protein binding, bridging|
|regulation of steroid biosynthetic process|
|histone deacetylase binding|
|regulation of steroid metabolic process|
|import into nucleus|
|female gamete generation|
|regulation of lipid biosynthetic process|
|ribonucleoprotein complex assembly|
|protein domain specific binding|
|ribonucleoprotein complex subunit organization|
|germ cell development|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|cellular process involved in reproduction in multicellular organism|
|cytoskeleton|
|regulation of lipid metabolic process|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|gamete generation|
|mRNA metabolic process|
|positive regulation of cell death|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|multi-organism reproductive process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|negative regulation of gene expression|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.4|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.06|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.06|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.94|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.9|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.88|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.84|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.79|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.78|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.76|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.73|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.594|
|[[:human genes:r:rpp21|RPP21]]|0.577|
|[[:human genes:v:vezt|VEZT]]|0.574|
|[[:human genes:a:alg1|ALG1]]|0.565|
|[[:human genes:r:rtcb|RTCB]]|0.551|
|[[:human genes:r:rnmt|RNMT]]|0.551|
|[[:human genes:y:yars|YARS]]|0.545|
|[[:human genes:g:gemin8|GEMIN8]]|0.539|
|[[:human genes:d:dpagt1|DPAGT1]]|0.536|
|[[:human genes:o:osgep|OSGEP]]|0.531|
|[[:human genes:h:hars|HARS]]|0.528|
|[[:human genes:g:gmppb|GMPPB]]|0.526|
|[[:human genes:g:gemin5|GEMIN5]]|0.525|
|[[:human genes:p:pmm2|PMM2]]|0.52|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.518|
|[[:human genes:d:dhps|DHPS]]|0.516|
|[[:human genes:n:nsmce1|NSMCE1]]|0.513|
|[[:human genes:g:gnb1l|GNB1L]]|0.509|
|[[:human genes:u:utp23|UTP23]]|0.509|
|[[:human genes:a:adsl|ADSL]]|0.507|
|[[:human genes:g:gemin6|GEMIN6]]|0.506|
|[[:human genes:p:pelo|PELO]]|0.5|
|[[:human genes:e:exoc3|EXOC3]]|0.5|
|[[:human genes:e:exoc4|EXOC4]]|0.497|
|[[:human genes:a:alg14|ALG14]]|0.496|
|[[:human genes:r:rbm14|RBM14]]|0.496|
|[[:human genes:t:tti2|TTI2]]|0.495|
|[[:human genes:u:uap1|UAP1]]|0.494|
|[[:human genes:t:triap1|TRIAP1]]|0.491|
|[[:human genes:v:vrk1|VRK1]]|0.49|
|[[:human genes:s:snapc5|SNAPC5]]|0.49|
|[[:human genes:p:ppp4c|PPP4C]]|0.489|
|[[:human genes:e:eno1|ENO1]]|0.488|
|[[:human genes:b:bub3|BUB3]]|0.485|
|[[:human genes:u:uxt|UXT]]|0.485|
|[[:human genes:d:dctn6|DCTN6]]|0.485|
|[[:human genes:u:uhrf1|UHRF1]]|0.484|
|[[:human genes:d:ddx55|DDX55]]|0.483|
|[[:human genes:t:taf1a|TAF1A]]|0.48|
|[[:human genes:n:nae1|NAE1]]|0.479|
|[[:human genes:s:srp14|SRP14]]|0.477|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.476|
|[[:human genes:e:eprs|EPRS]]|0.475|
|[[:human genes:m:med16|MED16]]|0.473|
|[[:human genes:z:zrsr2|ZRSR2]]|0.472|
|[[:human genes:g:gfpt1|GFPT1]]|0.472|
|[[:human genes:r:rabggtb|RABGGTB]]|0.471|
|[[:human genes:r:rpe|RPE]]|0.471|
|[[:human genes:f:fnta|FNTA]]|0.471|
|[[:human genes:p:polr3h|POLR3H]]|0.469|
|[[:human genes:t:telo2|TELO2]]|0.467|
|[[:human genes:t:tbca|TBCA]]|0.467|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.466|
|[[:human genes:a:atxn10|ATXN10]]|0.462|
|[[:human genes:g:gemin7|GEMIN7]]|0.462|
|[[:human genes:a:alg2|ALG2]]|0.459|
|[[:human genes:h:haus8|HAUS8]]|0.457|
|[[:human genes:t:ten1|TEN1]]|0.456|
|[[:human genes:m:mad2l1|MAD2L1]]|0.453|
|[[:human genes:t:timm22|TIMM22]]|0.449|
|[[:human genes:t:tti1|TTI1]]|0.449|
|[[:human genes:r:rptor|RPTOR]]|0.448|
|[[:human genes:p:ppcs|PPCS]]|0.445|
|[[:human genes:t:tbcb|TBCB]]|0.444|
|[[:human genes:t:txnl4b|TXNL4B]]|0.443|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.443|
|[[:human genes:d:ddost|DDOST]]|0.439|
|[[:human genes:z:zwilch|ZWILCH]]|0.438|
|[[:human genes:a:aars|AARS]]|0.438|
|[[:human genes:a:alg13|ALG13]]|0.437|
|[[:human genes:k:kntc1|KNTC1]]|0.437|
|[[:human genes:d:dohh|DOHH]]|0.436|
|[[:human genes:t:tsen34|TSEN34]]|0.435|
|[[:human genes:t:tsen54|TSEN54]]|0.435|
|[[:human genes:s:sugt1|SUGT1]]|0.434|
|[[:human genes:w:wdr92|WDR92]]|0.433|
|[[:human genes:d:dad1|DAD1]]|0.433|
|[[:human genes:h:hspd1|HSPD1]]|0.431|
|[[:human genes:p:pam16|PAM16]]|0.43|
|[[:human genes:r:rad1|RAD1]]|0.429|
|[[:human genes:f:fen1|FEN1]]|0.428|
|[[:human genes:p:pik3r4|PIK3R4]]|0.428|
|[[:human genes:n:nars|NARS]]|0.428|
|[[:human genes:d:dhrsx|DHRSX]]|0.427|
|[[:human genes:s:spcs2|SPCS2]]|0.425|
|[[:human genes:t:tma16|TMA16]]|0.425|
|[[:human genes:s:srp72|SRP72]]|0.423|
|[[:human genes:s:snf8|SNF8]]|0.423|
|[[:human genes:e:elac2|ELAC2]]|0.422|
|[[:human genes:t:ttc4|TTC4]]|0.422|
|[[:human genes:c:chchd4|CHCHD4]]|0.421|
|[[:human genes:c:cct7|CCT7]]|0.421|
|[[:human genes:t:tprkb|TPRKB]]|0.421|
|[[:human genes:w:wdr82|WDR82]]|0.42|
|[[:human genes:o:oraov1|ORAOV1]]|0.417|
|[[:human genes:k:kdm8|KDM8]]|0.417|
|[[:human genes:t:trnt1|TRNT1]]|0.416|
|[[:human genes:u:uba3|UBA3]]|0.415|
|[[:human genes:t:tgs1|TGS1]]|0.414|
|[[:human genes:e:eif4e|EIF4E]]|0.414|
|[[:human genes:p:pgk1|PGK1]]|0.414|
|[[:human genes:f:fh|FH]]|0.413|
|[[:human genes:l:lsm11|LSM11]]|0.412|
|[[:human genes:m:mars|MARS]]|0.41|
|[[:human genes:t:trmt5|TRMT5]]|0.407|
|[[:human genes:n:naa20|NAA20]]|0.407|
|[[:human genes:r:rpn1|RPN1]]|0.406|
|[[:human genes:c:cbfb|CBFB]]|0.406|
|[[:human genes:d:ddx39a|DDX39A]]|0.404|
|[[:human genes:d:dctn5|DCTN5]]|0.402|
|[[:human genes:c:cdipt|CDIPT]]|0.401|
|[[:human genes:v:vma21|VMA21]]|0.401|
|[[:human genes:m:mad1l1|MAD1L1]]|0.4|
|[[:human genes:r:rpia|RPIA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 124/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|4/28|
|bone|5/26|
|breast|7/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|3/21|
|liver|5/20|
|lung|15/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|4/24|
|peripheral nervous system|5/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|2/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1190
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX20 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>