DEFA3 [The Human Chemical-Genetic Interaction Map Project]

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======= DEFA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DEFA3
  * **<color #00a2e8>Official Name</color>**: defensin alpha 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1668|1668]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P59666|P59666]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DEFA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DEFA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604522|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15894545, ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:2006422}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Defensin 1|
|Defensin propep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|membrane disruption in other organism|
|innate immune response in mucosa|
|intracellular estrogen receptor signaling pathway|
|mucosal immune response|
|organ or tissue specific immune response|
|defense response to fungus|
|antibacterial humoral response|
|response to fungus|
|killing of cells of other organism|
|disruption of cells of other organism|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|intracellular steroid hormone receptor signaling pathway|
|defense response to Gram-negative bacterium|
|cell killing|
|azurophil granule lumen|
|defense response to Gram-positive bacterium|
|Golgi lumen|
|antimicrobial humoral response|
|steroid hormone mediated signaling pathway|
|modification of morphology or physiology of other organism|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cellular response to lipopolysaccharide|
|cellular response to steroid hormone stimulus|
|defense response to virus|
|cellular response to molecule of bacterial origin|
|cellular response to biotic stimulus|
|response to virus|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|defense response to bacterium|
|humoral immune response|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|response to bacterium|
|molecular function|
|innate immune response|
|interspecies interaction between organisms|
|response to lipid|
|protein homodimerization activity|
|response to hormone|
|response to organic cyclic compound|
|defense response to other organism|
|cellular response to oxygen-containing compound|
|immune effector process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12851
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DEFA3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>