DENND6A [The Human Chemical-Genetic Interaction Map Project]

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======= DENND6A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DENND6A
  * **<color #00a2e8>Official Name</color>**: DENN domain containing 6A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=201627|201627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWF6|Q8IWF6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DENND6A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DENND6A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620561|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes. {ECO:0000269|PubMed:22595670}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Afi1|
|Avl9|
|SPB interacting|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cell-cell adhesion mediated by cadherin|
|regulation of cell-cell adhesion mediated by cadherin|
|Rab guanyl-nucleotide exchange factor activity|
|recycling endosome|
|positive regulation of cell-cell adhesion|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.89|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.8|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.9|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4719
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DENND6A Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>