DGKD [The Human Chemical-Genetic Interaction Map Project]

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======= DGKD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DGKD
  * **<color #00a2e8>Official Name</color>**: diacylglycerol kinase delta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8527|8527]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16760|Q16760]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DGKD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DGKD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601826|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as signaling molecule. {ECO:0000269|PubMed:17880279}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 1|
|PH|
|DAGK acc|
|SAM 2|
|C1 1|
|DAGK cat|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diacylglycerol kinase activity|
|diacylglycerol binding|
|NAD+ kinase activity|
|diacylglycerol metabolic process|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|epidermal growth factor receptor signaling pathway|
|lipid phosphorylation|
|ERBB signaling pathway|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|platelet activation|
|lipid modification|
|blood coagulation|
|coagulation|
|hemostasis|
|second-messenger-mediated signaling|
|protein homooligomerization|
|glycerolipid metabolic process|
|wound healing|
|protein heterodimerization activity|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|endocytosis|
|response to wounding|
|import into cell|
|enzyme linked receptor protein signaling pathway|
|protein homodimerization activity|
|cellular lipid metabolic process|
|cell activation|
|lipid metabolic process|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|ATP binding|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|intracellular signal transduction|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.72|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.76|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.8|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.8|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.88|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.93|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.95|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.07|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.08|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.18|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.22|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.41|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.49|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.53|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.7|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.77|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.79|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.96|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nf1|NF1]]|0.468|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.431|
|[[:human genes:p:pmaip1|PMAIP1]]|0.427|
|[[:human genes:d:dusp6|DUSP6]]|0.427|
|[[:human genes:r:rfwd2|RFWD2]]|0.416|
|[[:human genes:r:rasa2|RASA2]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4813
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DGKD Expression in NALM6 Cells: 8.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>