DGKQ [The Human Chemical-Genetic Interaction Map Project]

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======= DGKQ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DGKQ
  * **<color #00a2e8>Official Name</color>**: diacylglycerol kinase theta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1609|1609]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52824|P52824]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DGKQ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DGKQ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601207|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:17664281}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAGK acc|
|RA|
|C1 1|
|DAGK cat|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of progesterone biosynthetic process|
|regulation of cortisol biosynthetic process|
|transmembrane receptor protein tyrosine kinase activator activity|
|regulation of glucocorticoid biosynthetic process|
|thrombin-activated receptor signaling pathway|
|regulation of glucocorticoid metabolic process|
|regulation of steroid hormone biosynthetic process|
|diacylglycerol kinase activity|
|activation of transmembrane receptor protein tyrosine kinase activity|
|protein kinase C signaling|
|phospholipase binding|
|regulation of ketone biosynthetic process|
|regulation of synaptic vesicle endocytosis|
|NAD+ kinase activity|
|negative regulation of peptidyl-threonine phosphorylation|
|diacylglycerol metabolic process|
|regulation of synaptic vesicle recycling|
|regulation of hormone biosynthetic process|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|vesicle membrane|
|response to ATP|
|activating transcription factor binding|
|regulation of hormone metabolic process|
|regulation of TORC1 signaling|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|regulation of peptidyl-threonine phosphorylation|
|regulation of gluconeogenesis|
|regulation of cholesterol metabolic process|
|lipid phosphorylation|
|regulation of alcohol biosynthetic process|
|postsynapse|
|regulation of steroid biosynthetic process|
|kinase binding|
|presynapse|
|regulation of carbohydrate biosynthetic process|
|response to cAMP|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|regulation of TOR signaling|
|nuclear matrix|
|regulation of synaptic vesicle cycle|
|regulation of glucose metabolic process|
|regulation of steroid metabolic process|
|response to organophosphorus|
|platelet activation|
|regulation of cellular carbohydrate metabolic process|
|regulation of G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|response to purine-containing compound|
|regulation of cellular ketone metabolic process|
|cyclic-nucleotide-mediated signaling|
|peptidyl-serine phosphorylation|
|regulation of lipid biosynthetic process|
|positive regulation of peptidyl-tyrosine phosphorylation|
|peptidyl-serine modification|
|lipid modification|
|regulation of carbohydrate metabolic process|
|regulation of endocytosis|
|glycerophospholipid biosynthetic process|
|response to nutrient|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|regulation of peptidyl-tyrosine phosphorylation|
|endosome|
|blood coagulation|
|coagulation|
|hemostasis|
|glycerophospholipid metabolic process|
|activation of protein kinase activity|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|cytoskeleton|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|nuclear speck|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|wound healing|
|regulation of body fluid levels|
|response to nutrient levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to extracellular stimulus|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|negative regulation of protein modification process|
|positive regulation of transferase activity|
|enzyme linked receptor protein signaling pathway|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|regulation of cellular localization|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|protein phosphorylation|
|regulation of transferase activity|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.81|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.84|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.9|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.464|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DGKQ Expression in NALM6 Cells: 4.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>