DHDH [The Human Chemical-Genetic Interaction Map Project]

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======= DHDH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHDH
  * **<color #00a2e8>Official Name</color>**: dihydrodiol dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27294|27294]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQ10|Q9UQ10]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHDH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHDH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606377|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GFO IDH MocA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|D-xylose 1-dehydrogenase (NADP+) activity|
|D-xylose catabolic process|
|NAD(P)+ transhydrogenase activity|
|D-xylose metabolic process|
|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|
|pentose catabolic process|
|pentose metabolic process|
|monosaccharide catabolic process|
|electron transfer activity|
|carbohydrate catabolic process|
|electron transport chain|
|monosaccharide metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|carbohydrate metabolic process|
|oxidation-reduction process|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.626|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8424
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHDH Expression in NALM6 Cells: -1.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>