DHX36 [The Human Chemical-Genetic Interaction Map Project]

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======= DHX36 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHX36
  * **<color #00a2e8>Official Name</color>**: DEAH-box helicase 36
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=170506|170506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2U1|Q9H2U1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHX36&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHX36|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612767|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398, ECO:0000269|PubMed:16150737, ECO:0000269|PubMed:18842585, ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21586581, ECO:0000269|PubMed:21993297, ECO:0000269|PubMed:22238380}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|OB NTP bind|
|HA2|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcription from RNA polymerase II promoter involved in spermatogenesis|
|regulation of intracellular mRNA localization|
|positive regulation of intracellular mRNA localization|
|cellular response to arsenite ion|
|response to arsenite ion|
|telomerase RNA stabilization|
|positive regulation of hematopoietic progenitor cell differentiation|
|regulation of myeloid dendritic cell cytokine production|
|positive regulation of myeloid dendritic cell cytokine production|
|pre-miRNA binding|
|positive regulation of cardioblast differentiation|
|G-quadruplex RNA binding|
|G-quadruplex DNA unwinding|
|positive regulation of dendritic cell cytokine production|
|RNA secondary structure unwinding|
|regulation of cardioblast differentiation|
|G-quadruplex DNA binding|
|positive regulation of interferon-alpha secretion|
|regulation of interferon-alpha secretion|
|positive regulation of cytoplasmic translation|
|positive regulation of mRNA 3-end processing|
|regulation of dendritic cell cytokine production|
|3-UTR-mediated mRNA destabilization|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|3-5 RNA helicase activity|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|positive regulation of transcription initiation from RNA polymerase II promoter|
|cellular response to arsenic-containing substance|
|positive regulation of dendritic spine morphogenesis|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of stem cell differentiation|
|telomerase RNA binding|
|positive regulation of interferon-alpha production|
|regulation of transcription by RNA polymerase III|
|mRNA 5-UTR binding|
|positive regulation of DNA-templated transcription, initiation|
|mRNA 3-UTR AU-rich region binding|
|regulation of transcription initiation from RNA polymerase II promoter|
|positive regulation of cardiocyte differentiation|
|regulation of mRNA 3-end processing|
|regulation of interferon-alpha production|
|mRNA destabilization|
|regulation of cytoplasmic translation|
|positive regulation of myeloid leukocyte mediated immunity|
|positive regulation of mRNA processing|
|RNA destabilization|
|response to arsenic-containing substance|
|regulation of DNA-templated transcription, initiation|
|positive regulation of telomere maintenance via telomere lengthening|
|positive regulation of dendrite morphogenesis|
|regulation of dendritic spine morphogenesis|
|positive regulation of dendritic spine development|
|DNA-dependent ATPase activity|
|response to exogenous dsRNA|
|positive regulation of mRNA catabolic process|
|RNA stabilization|
|regulation of cardiocyte differentiation|
|positive regulation of telomere maintenance|
|chromosome, telomeric region|
|response to dsRNA|
|positive regulation of cytokine production involved in immune response|
|regulation of myeloid leukocyte mediated immunity|
|negative regulation of RNA catabolic process|
|DNA helicase activity|
|regulation of telomere maintenance via telomere lengthening|
|RNA helicase activity|
|cytoplasmic stress granule|
|cellular response to heat|
|double-stranded RNA binding|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|mRNA 3-UTR binding|
|positive regulation of type I interferon production|
|positive regulation of mRNA metabolic process|
|regulation of telomere maintenance|
|cellular response to UV|
|regulation of cytokine production involved in immune response|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|positive regulation of production of molecular mediator of immune response|
|single-stranded DNA binding|
|response to heat|
|DNA duplex unwinding|
|histone deacetylase binding|
|cellular response to light stimulus|
|regulation of stem cell differentiation|
|DNA geometric change|
|positive regulation of translation|
|regulation of type I interferon production|
|regulation of embryonic development|
|negative regulation of translation|
|positive regulation of leukocyte mediated immunity|
|perikaryon|
|regulation of mRNA processing|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|response to UV|
|negative regulation of cellular amide metabolic process|
|regulation of dendrite development|
|positive regulation of cellular amide metabolic process|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to radiation|
|positive regulation of chromosome organization|
|response to temperature stimulus|
|regulation of mRNA stability|
|regulation of RNA stability|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of hemopoiesis|
|defense response to virus|
|positive regulation of DNA metabolic process|
|regulation of mRNA catabolic process|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|magnesium ion binding|
|transcription regulatory region DNA binding|
|regulation of synapse organization|
|positive regulation of immune effector process|
|regulation of synapse structure or activity|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of cellular catabolic process|
|ossification|
|positive regulation of protein secretion|
|positive regulation of neuron projection development|
|response to virus|
|positive regulation of peptide secretion|
|axon|
|DNA conformation change|
|regulation of cell morphogenesis involved in differentiation|
|response to light stimulus|
|negative regulation of catabolic process|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|regulation of translation|
|regulation of DNA metabolic process|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|nuclear speck|
|positive regulation of secretion by cell|
|regulation of cellular amide metabolic process|
|dendrite|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|positive regulation of secretion|
|response to radiation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|posttranscriptional regulation of gene expression|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|spermatogenesis|
|male gamete generation|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|regulation of secretion|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|positive regulation of immune response|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|defense response to other organism|
|positive regulation of cell differentiation|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|response to nitrogen compound|
|immune effector process|
|negative regulation of protein metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|mitochondrion|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-3.7|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.84|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.79|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.73|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.71|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.45|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.35|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.18|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.18|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.05|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.96|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.91|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.89|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.89|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.86|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.82|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.79|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.74|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.74|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.71|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.71|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 43/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|4/25|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|2/21|
|liver|1/20|
|lung|7/75|
|lymphocyte|3/14|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2183
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHX36 Expression in NALM6 Cells: 7.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>