DIMT1 [The Human Chemical-Genetic Interaction Map Project]

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======= DIMT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DIMT1
  * **<color #00a2e8>Official Name</color>**: DIMT1 rRNA methyltransferase and ribosome maturation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27292|27292]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNQ2|Q9UNQ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DIMT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DIMT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612499|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). {ECO:0000269|PubMed:25851604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 18|
|RrnaAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity|
|rRNA (adenine-N6,N6-)-dimethyltransferase activity|
|positive regulation of ribosome biogenesis|
|positive regulation of rRNA processing|
|regulation of rRNA processing|
|regulation of ribosome biogenesis|
|rRNA methylation|
|rRNA modification|
|RNA methylation|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|mitochondrial matrix|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|positive regulation of cellular component biogenesis|
|nucleolus|
|RNA processing|
|regulation of cellular component biogenesis|
|RNA binding|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.74|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.75|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr75|WDR75]]|0.479|
|[[:human genes:r:rps12|RPS12]]|0.464|
|[[:human genes:u:utp20|UTP20]]|0.463|
|[[:human genes:g:golga8j|GOLGA8J]]|0.449|
|[[:human genes:r:rrp9|RRP9]]|0.445|
|[[:human genes:s:sf3a3|SF3A3]]|0.444|
|[[:human genes:p:psmb2|PSMB2]]|0.435|
|[[:human genes:g:golga8k|GOLGA8K]]|0.433|
|[[:human genes:r:rpl35|RPL35]]|0.42|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.42|
|[[:human genes:d:dhx38|DHX38]]|0.416|
|[[:human genes:p:pdcd11|PDCD11]]|0.415|
|[[:human genes:r:rps2|RPS2]]|0.413|
|[[:human genes:u:utp3|UTP3]]|0.411|
|[[:human genes:n:nol10|NOL10]]|0.406|
|[[:human genes:n:ncl|NCL]]|0.405|
|[[:human genes:s:snip1|SNIP1]]|0.404|
|[[:human genes:n:narfl|NARFL]]|0.403|
|[[:human genes:t:tspy2|TSPY2]]|0.403|
|[[:human genes:c:ctage4|CTAGE4]]|0.402|
|[[:human genes:r:rrp7a|RRP7A]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1593
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DIMT1 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>