DLGAP5 [The Human Chemical-Genetic Interaction Map Project]

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======= DLGAP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLGAP5
  * **<color #00a2e8>Official Name</color>**: DLG associated protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9787|9787]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15398|Q15398]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLGAP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLGAP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617859|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269|PubMed:12527899, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15145941}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GKAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic chromosome movement towards spindle pole|
|chromosome movement towards spindle pole|
|positive regulation of mitotic sister chromatid separation|
|positive regulation of mitotic metaphase/anaphase transition|
|positive regulation of metaphase/anaphase transition of cell cycle|
|positive regulation of chromosome separation|
|spindle pole centrosome|
|positive regulation of mitotic sister chromatid segregation|
|positive regulation of transcription of Notch receptor target|
|positive regulation of chromosome segregation|
|phosphoprotein phosphatase activity|
|regulation of mitotic metaphase/anaphase transition|
|positive regulation of mitotic nuclear division|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|positive regulation of nuclear division|
|regulation of mitotic sister chromatid segregation|
|establishment of chromosome localization|
|chromosome localization|
|positive regulation of mitotic cell cycle phase transition|
|regulation of sister chromatid segregation|
|positive regulation of cell cycle phase transition|
|regulation of chromosome segregation|
|mitotic sister chromatid segregation|
|Notch signaling pathway|
|sister chromatid segregation|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|microtubule organizing center|
|regulation of mitotic nuclear division|
|positive regulation of chromosome organization|
|regulation of nuclear division|
|protein dephosphorylation|
|nuclear chromosome segregation|
|microtubule-based movement|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|dephosphorylation|
|organelle fission|
|regulation of chromosome organization|
|establishment of organelle localization|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell population proliferation|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|mitochondrion|
|regulation of organelle organization|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|establishment of localization in cell|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-4.35|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-3.95|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-3.66|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-3.39|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.37|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-3.24|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-3.23|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-3.16|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-3.1|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-3.1|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.98|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.95|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.87|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.77|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.71|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.65|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.56|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.49|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.46|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.3|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.2|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.15|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.13|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.13|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.09|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.08|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.92|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.76|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.76|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tacc3|TACC3]]|0.75|
|[[:human genes:k:kif15|KIF15]]|0.625|
|[[:human genes:a:aspm|ASPM]]|0.586|
|[[:human genes:g:gak|GAK]]|0.585|
|[[:human genes:g:gtse1|GTSE1]]|0.58|
|[[:human genes:g:gsg2|GSG2]]|0.525|
|[[:human genes:k:klf16|KLF16]]|0.5|
|[[:human genes:c:cdca2|CDCA2]]|0.489|
|[[:human genes:s:sephs1|SEPHS1]]|0.468|
|[[:human genes:m:mapre1|MAPRE1]]|0.461|
|[[:human genes:e:esco2|ESCO2]]|0.429|
|[[:human genes:c:calm2|CALM2]]|0.427|
|[[:human genes:l:lrrc8a|LRRC8A]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6935
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLGAP5 Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>