DMRT1 [The Human Chemical-Genetic Interaction Map Project]

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======= DMRT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DMRT1
  * **<color #00a2e8>Official Name</color>**: doublesex and mab-3 related transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1761|1761]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5R6|Q9Y5R6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DMRT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DMRT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602424|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dmrt1|
|DM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|germ cell proliferation|
|male germ cell proliferation|
|positive regulation of meiosis I|
|regulation of meiosis I|
|positive regulation of male gonad development|
|regulation of nodal signaling pathway|
|germ cell migration|
|regulation of male gonad development|
|positive regulation of gonad development|
|negative regulation of meiotic nuclear division|
|Sertoli cell development|
|positive regulation of meiotic nuclear division|
|male sex determination|
|negative regulation of meiotic cell cycle|
|regulation of gonad development|
|Sertoli cell differentiation|
|sex determination|
|positive regulation of meiotic cell cycle|
|regulation of activin receptor signaling pathway|
|regulation of meiotic nuclear division|
|proximal promoter sequence-specific DNA binding|
|oocyte development|
|oocyte differentiation|
|negative regulation of nuclear division|
|regulation of meiotic cell cycle|
|positive regulation of mitotic nuclear division|
|negative regulation of reproductive process|
|positive regulation of nuclear division|
|oogenesis|
|positive regulation of reproductive process|
|female gamete generation|
|male gonad development|
|development of primary male sexual characteristics|
|positive regulation of mitotic cell cycle|
|male sex differentiation|
|regulation of reproductive process|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|epithelial cell development|
|gonad development|
|development of primary sexual characteristics|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|germ cell development|
|sex differentiation|
|positive regulation of cell cycle process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of cell cycle process|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|chromatin binding|
|reproductive structure development|
|reproductive system development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|protein heterodimerization activity|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|negative regulation of cell cycle|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|gamete generation|
|negative regulation of cellular component organization|
|cell morphogenesis|
|regulation of cell cycle process|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|cell migration|
|multi-organism reproductive process|
|identical protein binding|
|localization of cell|
|cell motility|
|epithelium development|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7225
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DMRT1 Expression in NALM6 Cells: 0.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>