DMRT3 [The Human Chemical-Genetic Interaction Map Project]

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======= DMRT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DMRT3
  * **<color #00a2e8>Official Name</color>**: doublesex and mab-3 related transcription factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58524|58524]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQL9|Q9NQL9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DMRT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DMRT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614754|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DMA|
|DM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell fate specification involved in pattern specification|
|ventral spinal cord interneuron specification|
|regulation of odontogenesis of dentin-containing tooth|
|cell fate commitment involved in pattern specification|
|ventral spinal cord interneuron fate commitment|
|ventral spinal cord interneuron differentiation|
|spinal cord dorsal/ventral patterning|
|spinal cord patterning|
|regulation of odontogenesis|
|adult walking behavior|
|walking behavior|
|neuron fate specification|
|ventral spinal cord development|
|cell differentiation in spinal cord|
|transmission of nerve impulse|
|neuron fate commitment|
|adult locomotory behavior|
|dorsal/ventral pattern formation|
|cell fate specification|
|spinal cord development|
|multicellular organismal signaling|
|adult behavior|
|male sex differentiation|
|central nervous system neuron differentiation|
|locomotory behavior|
|cell fate commitment|
|regulation of animal organ morphogenesis|
|sex differentiation|
|regionalization|
|sequence-specific DNA binding|
|pattern specification process|
|protein heterodimerization activity|
|behavior|
|developmental process involved in reproduction|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|nervous system process|
|reproductive process|
|reproduction|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.76|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.76|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.74|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15284
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DMRT3 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>