DNAH3 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAH3
  * **<color #00a2e8>Official Name</color>**: dynein axonemal heavy chain 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55567|55567]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TD57|Q8TD57]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603334|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynein heavy|
|AAA 7|
|AAA 6|
|AAA 9|
|MT|
|AAA 8|
|DHC N2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inner dynein arm|
|axonemal dynein complex|
|ATP-dependent microtubule motor activity, minus-end-directed|
|dynein complex|
|dynein light chain binding|
|dynein intermediate chain binding|
|dynein light intermediate chain binding|
|cilium movement|
|microtubule motor activity|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|microtubule-based movement|
|microtubule|
|microtubule-based process|
|cell motility|
|localization of cell|
|locomotion|
|ATP binding|
|movement of cell or subcellular component|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.41|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.86|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.86|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.8|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.78|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.612|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13623
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAH3 Expression in NALM6 Cells: 1.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>