DNAH8 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAH8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAH8
  * **<color #00a2e8>Official Name</color>**: dynein axonemal heavy chain 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1769|1769]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JB1|Q96JB1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAH8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAH8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603337|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA 7|
|DHC N1|
|DHC N2|
|AAA 5|
|Dynein heavy|
|AAA 9|
|MT|
|AAA 6|
|AAA 8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|outer dynein arm|
|axonemal dynein complex|
|outer dynein arm assembly|
|ATP-dependent microtubule motor activity, minus-end-directed|
|dynein complex|
|dynein light chain binding|
|dynein light intermediate chain binding|
|dynein intermediate chain binding|
|axonemal dynein complex assembly|
|axoneme assembly|
|microtubule motor activity|
|microtubule bundle formation|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|microtubule-based movement|
|microtubule|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|microtubule-based process|
|organelle assembly|
|cellular protein-containing complex assembly|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|ATP binding|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-2.09|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.72|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.83|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12437
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAH8 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>