DNAJA3 [The Human Chemical-Genetic Interaction Map Project]

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======= DNAJA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJA3
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9093|9093]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EY1|Q96EY1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608382|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
|DnaJ CXXCXGXG|
|DnaJ C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation-induced cell death of T cells|
|skeletal muscle acetylcholine-gated channel clustering|
|mitochondrial DNA replication|
|GTPase regulator activity|
|T cell apoptotic process|
|lymphocyte apoptotic process|
|leukocyte apoptotic process|
|postsynaptic membrane organization|
|extrinsic component of plasma membrane|
|T cell homeostasis|
|Hsp70 protein binding|
|neuromuscular junction development|
|receptor clustering|
|T cell differentiation in thymus|
|lymphocyte homeostasis|
|cell aging|
|leukocyte homeostasis|
|neuromuscular junction|
|actin filament|
|localization within membrane|
|postsynapse organization|
|positive regulation of T cell proliferation|
|response to heat|
|DNA-dependent DNA replication|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|unfolded protein binding|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|regulation of T cell proliferation|
|response to temperature stimulus|
|homeostasis of number of cells|
|postsynaptic membrane|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|DNA replication|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|protein folding|
|T cell activation|
|lymphocyte differentiation|
|positive regulation of cell-cell adhesion|
|synapse organization|
|aging|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|leukocyte differentiation|
|positive regulation of lymphocyte activation|
|mitochondrial matrix|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|mitochondrion organization|
|protein localization to membrane|
|regulation of lymphocyte activation|
|cell junction|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|membrane organization|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|negative regulation of cell death|
|programmed cell death|
|cell activation|
|cell death|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.73|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.85|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.99|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.564|
|[[:human genes:h:hars|HARS]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 168/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|5/28|
|bone|8/26|
|breast|8/33|
|central nervous system|17/56|
|cervix|2/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|4/21|
|liver|6/20|
|lung|18/75|
|lymphocyte|3/16|
|ovary|4/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|7/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|9/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 329
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJA3 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>