DNASE2 [The Human Chemical-Genetic Interaction Map Project]

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======= DNASE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNASE2
  * **<color #00a2e8>Official Name</color>**: deoxyribonuclease 2, lysosomal
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1777|1777]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00115|O00115]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNASE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNASE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNase II|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deoxyribonuclease II activity|
|apoptotic DNA fragmentation|
|DNA catabolic process, endonucleolytic|
|apoptotic nuclear changes|
|cellular component disassembly involved in execution phase of apoptosis|
|DNA catabolic process|
|execution phase of apoptosis|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|myeloid cell homeostasis|
|homeostasis of number of cells|
|myeloid cell differentiation|
|lysosome|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|cellular component disassembly|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|DNA metabolic process|
|cellular macromolecule catabolic process|
|apoptotic process|
|macromolecule catabolic process|
|programmed cell death|
|cell death|
|regulation of immune response|
|DNA binding|
|homeostatic process|
|regulation of immune system process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4214
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNASE2 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>