DNTTIP2 [The Human Chemical-Genetic Interaction Map Project]

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======= DNTTIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNTTIP2
  * **<color #00a2e8>Official Name</color>**: deoxynucleotidyltransferase terminal interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30836|30836]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5QJE6|Q5QJE6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNTTIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNTTIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611199|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fcf2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolus|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.15|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.81|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.85|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.93|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.95|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.53|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb2|PSMB2]]|0.563|
|[[:human genes:o:orc1|ORC1]]|0.542|
|[[:human genes:r:rpl35|RPL35]]|0.514|
|[[:human genes:o:ogfr|OGFR]]|0.511|
|[[:human genes:p:psmb4|PSMB4]]|0.51|
|[[:human genes:p:psmd3|PSMD3]]|0.503|
|[[:human genes:z:znf830|ZNF830]]|0.503|
|[[:human genes:k:kctd17|KCTD17]]|0.502|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.5|
|[[:human genes:p:psmc6|PSMC6]]|0.494|
|[[:human genes:l:lrr1|LRR1]]|0.493|
|[[:human genes:t:twistnb|TWISTNB]]|0.492|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.489|
|[[:human genes:r:rpl37a|RPL37A]]|0.485|
|[[:human genes:p:psma6|PSMA6]]|0.483|
|[[:human genes:s:syt9|SYT9]]|0.482|
|[[:human genes:n:nupl1|NUPL1]]|0.481|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.481|
|[[:human genes:c:chd4|CHD4]]|0.474|
|[[:human genes:n:nbpf10|NBPF10]]|0.473|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.473|
|[[:human genes:c:cactin|CACTIN]]|0.472|
|[[:human genes:a:akirin2|AKIRIN2]]|0.47|
|[[:human genes:t:tfip11|TFIP11]]|0.47|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.469|
|[[:human genes:s:slc4a1|SLC4A1]]|0.468|
|[[:human genes:p:psmd1|PSMD1]]|0.467|
|[[:human genes:c:cope|COPE]]|0.466|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.466|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.465|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.465|
|[[:human genes:p:prim1|PRIM1]]|0.463|
|[[:human genes:n:nol10|NOL10]]|0.46|
|[[:human genes:c:cbwd3|CBWD3]]|0.459|
|[[:human genes:p:polr2a|POLR2A]]|0.458|
|[[:human genes:r:rrn3|RRN3]]|0.458|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.457|
|[[:human genes:v:vasn|VASN]]|0.457|
|[[:human genes:a:aqr|AQR]]|0.457|
|[[:human genes:z:znf106|ZNF106]]|0.454|
|[[:human genes:s:sel1l|SEL1L]]|0.453|
|[[:human genes:p:pigs|PIGS]]|0.453|
|[[:human genes:m:med17|MED17]]|0.452|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.451|
|[[:human genes:g:golga6a|GOLGA6A]]|0.448|
|[[:human genes:r:rps12|RPS12]]|0.447|
|[[:human genes:f:fbxw9|FBXW9]]|0.447|
|[[:human genes:c:cdc6|CDC6]]|0.446|
|[[:human genes:o:orc6|ORC6]]|0.444|
|[[:human genes:i:ik|IK]]|0.444|
|[[:human genes:d:dtl|DTL]]|0.444|
|[[:human genes:s:smg1|SMG1]]|0.444|
|[[:human genes:m:med14|MED14]]|0.443|
|[[:human genes:p:ppfia4|PPFIA4]]|0.443|
|[[:human genes:t:tceb3c|TCEB3C]]|0.443|
|[[:human genes:c:copb1|COPB1]]|0.442|
|[[:human genes:p:psmd7|PSMD7]]|0.442|
|[[:human genes:d:ddx23|DDX23]]|0.442|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.442|
|[[:human genes:z:znf655|ZNF655]]|0.439|
|[[:human genes:c:col2a1|COL2A1]]|0.438|
|[[:human genes:p:pole|POLE]]|0.437|
|[[:human genes:r:riok2|RIOK2]]|0.437|
|[[:human genes:n:nup205|NUP205]]|0.437|
|[[:human genes:t:top1mt|TOP1MT]]|0.436|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.435|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.435|
|[[:human genes:p:psmd11|PSMD11]]|0.435|
|[[:human genes:h:hap1|HAP1]]|0.434|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.434|
|[[:human genes:n:nup153|NUP153]]|0.434|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.434|
|[[:human genes:l:loc643669|LOC643669]]|0.433|
|[[:human genes:a:ankle1|ANKLE1]]|0.433|
|[[:human genes:s:supt6h|SUPT6H]]|0.432|
|[[:human genes:r:rpl34|RPL34]]|0.432|
|[[:human genes:m:mfsd12|MFSD12]]|0.431|
|[[:human genes:c:cdca3|CDCA3]]|0.431|
|[[:human genes:u:ubap1|UBAP1]]|0.431|
|[[:human genes:t:tyms|TYMS]]|0.43|
|[[:human genes:p:pbxip1|PBXIP1]]|0.43|
|[[:human genes:s:slc38a7|SLC38A7]]|0.43|
|[[:human genes:g:gar1|GAR1]]|0.429|
|[[:human genes:e:exosc9|EXOSC9]]|0.429|
|[[:human genes:c:cbwd5|CBWD5]]|0.429|
|[[:human genes:m:mylk3|MYLK3]]|0.429|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.428|
|[[:human genes:g:golga8j|GOLGA8J]]|0.426|
|[[:human genes:c:copg1|COPG1]]|0.426|
|[[:human genes:p:pan3|PAN3]]|0.425|
|[[:human genes:c:cbwd6|CBWD6]]|0.425|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.424|
|[[:human genes:z:zfand5|ZFAND5]]|0.424|
|[[:human genes:p:prpf8|PRPF8]]|0.424|
|[[:human genes:c:cdc73|CDC73]]|0.423|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.422|
|[[:human genes:p:psmc1|PSMC1]]|0.42|
|[[:human genes:c:chaf1a|CHAF1A]]|0.419|
|[[:human genes:x:xylt2|XYLT2]]|0.417|
|[[:human genes:r:rps7|RPS7]]|0.417|
|[[:human genes:p:pwp2|PWP2]]|0.416|
|[[:human genes:d:dock6|DOCK6]]|0.416|
|[[:human genes:m:msh5|MSH5]]|0.416|
|[[:human genes:d:ddtl|DDTL]]|0.415|
|[[:human genes:p:psmb1|PSMB1]]|0.414|
|[[:human genes:g:gid4|GID4]]|0.414|
|[[:human genes:a:adra1d|ADRA1D]]|0.413|
|[[:human genes:u:upf1|UPF1]]|0.413|
|[[:human genes:p:pan2|PAN2]]|0.412|
|[[:human genes:r:rps28|RPS28]]|0.412|
|[[:human genes:n:nup133|NUP133]]|0.412|
|[[:human genes:c:c14orf93|C14orf93]]|0.411|
|[[:human genes:c:ckap5|CKAP5]]|0.411|
|[[:human genes:r:ranbp2|RANBP2]]|0.411|
|[[:human genes:s:slc6a17|SLC6A17]]|0.411|
|[[:human genes:g:gpx4|GPX4]]|0.411|
|[[:human genes:s:supt5h|SUPT5H]]|0.41|
|[[:human genes:s:s1pr4|S1PR4]]|0.41|
|[[:human genes:p:psmd6|PSMD6]]|0.41|
|[[:human genes:r:rrp15|RRP15]]|0.409|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.409|
|[[:human genes:c:cln6|CLN6]]|0.409|
|[[:human genes:n:nup85|NUP85]]|0.409|
|[[:human genes:t:tspy8|TSPY8]]|0.408|
|[[:human genes:n:npipb5|NPIPB5]]|0.408|
|[[:human genes:t:ticrr|TICRR]]|0.407|
|[[:human genes:a:add2|ADD2]]|0.407|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.407|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.406|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.406|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.406|
|[[:human genes:p:polr2j3|POLR2J3]]|0.405|
|[[:human genes:x:xab2|XAB2]]|0.405|
|[[:human genes:k:krt78|KRT78]]|0.405|
|[[:human genes:s:sec13|SEC13]]|0.405|
|[[:human genes:r:rpl6|RPL6]]|0.404|
|[[:human genes:t:timeless|TIMELESS]]|0.404|
|[[:human genes:c:chmp2a|CHMP2A]]|0.404|
|[[:human genes:s:snrpa1|SNRPA1]]|0.403|
|[[:human genes:r:rrp7a|RRP7A]]|0.403|
|[[:human genes:l:lipe|LIPE]]|0.403|
|[[:human genes:f:fam160a1|FAM160A1]]|0.402|
|[[:human genes:m:mau2|MAU2]]|0.402|
|[[:human genes:i:igfn1|IGFN1]]|0.402|
|[[:human genes:p:psmd2|PSMD2]]|0.401|
|[[:human genes:s:slc5a5|SLC5A5]]|0.401|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.4|
|[[:human genes:b:bysl|BYSL]]|0.4|
|[[:human genes:t:terf2|TERF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1745
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNTTIP2 Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>