DOCK5 [The Human Chemical-Genetic Interaction Map Project]

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======= DOCK5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOCK5
  * **<color #00a2e8>Official Name</color>**: dedicator of cytokinesis 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80005|80005]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7D0|Q9H7D0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOCK5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOCK5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616904|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). {ECO:0000250|UniProtKB:B2RY04, ECO:0000269|PubMed:19004829}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|Ded cyto|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of vascular smooth muscle contraction|
|negative regulation of vasoconstriction|
|regulation of vascular smooth muscle contraction|
|negative regulation of smooth muscle contraction|
|positive regulation of vascular associated smooth muscle cell migration|
|regulation of vascular associated smooth muscle cell migration|
|negative regulation of muscle contraction|
|negative regulation of blood circulation|
|positive regulation of substrate adhesion-dependent cell spreading|
|positive regulation of smooth muscle cell migration|
|regulation of substrate adhesion-dependent cell spreading|
|positive regulation of blood vessel diameter|
|regulation of vasoconstriction|
|regulation of smooth muscle contraction|
|regulation of smooth muscle cell migration|
|guanyl-nucleotide exchange factor activity|
|positive regulation of cell-substrate adhesion|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|positive regulation of epithelial cell migration|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of muscle contraction|
|vascular process in circulatory system|
|regulation of cell-substrate adhesion|
|regulation of epithelial cell migration|
|regulation of muscle system process|
|GTPase activator activity|
|regulation of blood circulation|
|regulation of cell morphogenesis involved in differentiation|
|small GTPase mediated signal transduction|
|blood circulation|
|circulatory system process|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|regulation of system process|
|regulation of cell adhesion|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.85|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.72|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.71|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7519
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOCK5 Expression in NALM6 Cells: 3.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>