DOCK6 [The Human Chemical-Genetic Interaction Map Project]

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======= DOCK6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOCK6
  * **<color #00a2e8>Official Name</color>**: dedicator of cytokinesis 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57572|57572]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HP0|Q96HP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOCK6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOCK6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614194|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity). {ECO:0000250, ECO:0000269|PubMed:17196961}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ded cyto|
|DUF3398|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|guanyl-nucleotide exchange factor activity|
|blood coagulation|
|coagulation|
|hemostasis|
|small GTPase mediated signal transduction|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|perinuclear region of cytoplasm|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.96|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.86|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.7|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.76|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.8|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.83|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.91|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.01|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.05|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmd3|PSMD3]]|0.572|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.531|
|[[:human genes:f:fam160a1|FAM160A1]]|0.523|
|[[:human genes:t:ticrr|TICRR]]|0.519|
|[[:human genes:n:nupl1|NUPL1]]|0.518|
|[[:human genes:a:add2|ADD2]]|0.502|
|[[:human genes:n:nsf|NSF]]|0.501|
|[[:human genes:t:tceb3c|TCEB3C]]|0.5|
|[[:human genes:a:ankle2|ANKLE2]]|0.497|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.496|
|[[:human genes:f:fam231a|FAM231A]]|0.496|
|[[:human genes:f:fam231c|FAM231C]]|0.496|
|[[:human genes:p:pold1|POLD1]]|0.495|
|[[:human genes:a:ankle1|ANKLE1]]|0.494|
|[[:human genes:p:pole|POLE]]|0.494|
|[[:human genes:s:supt5h|SUPT5H]]|0.492|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.491|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.489|
|[[:human genes:c:c14orf93|C14orf93]]|0.486|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.483|
|[[:human genes:s:slc4a1|SLC4A1]]|0.481|
|[[:human genes:s:sec13|SEC13]]|0.474|
|[[:human genes:c:copg1|COPG1]]|0.474|
|[[:human genes:u:utp3|UTP3]]|0.47|
|[[:human genes:c:chd4|CHD4]]|0.469|
|[[:human genes:c:cdc45|CDC45]]|0.466|
|[[:human genes:s:snip1|SNIP1]]|0.465|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.464|
|[[:human genes:i:igfn1|IGFN1]]|0.463|
|[[:human genes:o:orc6|ORC6]]|0.462|
|[[:human genes:r:rrn3|RRN3]]|0.462|
|[[:human genes:m:mt1e|MT1E]]|0.462|
|[[:human genes:a:aamp|AAMP]]|0.461|
|[[:human genes:a:acsf2|ACSF2]]|0.461|
|[[:human genes:v:vasn|VASN]]|0.461|
|[[:human genes:c:cdh24|CDH24]]|0.457|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.456|
|[[:human genes:t:tfip11|TFIP11]]|0.456|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.455|
|[[:human genes:c:chaf1a|CHAF1A]]|0.455|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.455|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.455|
|[[:human genes:t:tyms|TYMS]]|0.455|
|[[:human genes:s:slc6a17|SLC6A17]]|0.454|
|[[:human genes:r:rrp15|RRP15]]|0.451|
|[[:human genes:i:ik|IK]]|0.45|
|[[:human genes:p:plekha4|PLEKHA4]]|0.45|
|[[:human genes:d:ddtl|DDTL]]|0.45|
|[[:human genes:n:nup160|NUP160]]|0.449|
|[[:human genes:d:dtl|DTL]]|0.447|
|[[:human genes:p:psmb4|PSMB4]]|0.447|
|[[:human genes:e:exosc3|EXOSC3]]|0.446|
|[[:human genes:v:vps28|VPS28]]|0.445|
|[[:human genes:c:cdc73|CDC73]]|0.445|
|[[:human genes:p:pan3|PAN3]]|0.444|
|[[:human genes:c:copa|COPA]]|0.444|
|[[:human genes:e:exosc6|EXOSC6]]|0.444|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.443|
|[[:human genes:k:kctd17|KCTD17]]|0.441|
|[[:human genes:n:narfl|NARFL]]|0.441|
|[[:human genes:c:ccna2|CCNA2]]|0.441|
|[[:human genes:c:cope|COPE]]|0.44|
|[[:human genes:g:gramd1a|GRAMD1A]]|0.437|
|[[:human genes:s:sel1l|SEL1L]]|0.437|
|[[:human genes:p:pno1|PNO1]]|0.437|
|[[:human genes:e:exosc9|EXOSC9]]|0.436|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.436|
|[[:human genes:x:xylt2|XYLT2]]|0.436|
|[[:human genes:g:golga8o|GOLGA8O]]|0.434|
|[[:human genes:t:tspy8|TSPY8]]|0.434|
|[[:human genes:i:ints4|INTS4]]|0.434|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.434|
|[[:human genes:c:cmya5|CMYA5]]|0.433|
|[[:human genes:r:ranbp2|RANBP2]]|0.433|
|[[:human genes:z:znf541|ZNF541]]|0.433|
|[[:human genes:c:col2a1|COL2A1]]|0.432|
|[[:human genes:g:golga6a|GOLGA6A]]|0.432|
|[[:human genes:h:hivep3|HIVEP3]]|0.431|
|[[:human genes:z:zfand5|ZFAND5]]|0.43|
|[[:human genes:h:hap1|HAP1]]|0.429|
|[[:human genes:p:ppfia4|PPFIA4]]|0.429|
|[[:human genes:c:cln6|CLN6]]|0.428|
|[[:human genes:p:psma6|PSMA6]]|0.428|
|[[:human genes:c:cdca3|CDCA3]]|0.427|
|[[:human genes:c:crnkl1|CRNKL1]]|0.426|
|[[:human genes:p:plk1|PLK1]]|0.425|
|[[:human genes:r:rps2|RPS2]]|0.424|
|[[:human genes:g:gar1|GAR1]]|0.423|
|[[:human genes:k:krt78|KRT78]]|0.422|
|[[:human genes:p:polr2a|POLR2A]]|0.421|
|[[:human genes:d:disp2|DISP2]]|0.419|
|[[:human genes:c:cep192|CEP192]]|0.419|
|[[:human genes:r:rhbdf1|RHBDF1]]|0.419|
|[[:human genes:c:cbwd3|CBWD3]]|0.419|
|[[:human genes:i:itga2b|ITGA2B]]|0.418|
|[[:human genes:c:copb1|COPB1]]|0.418|
|[[:human genes:o:orc1|ORC1]]|0.416|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.416|
|[[:human genes:e:eif4a3|EIF4A3]]|0.416|
|[[:human genes:t:twistnb|TWISTNB]]|0.415|
|[[:human genes:p:pigs|PIGS]]|0.415|
|[[:human genes:l:loc643669|LOC643669]]|0.415|
|[[:human genes:u:utp20|UTP20]]|0.414|
|[[:human genes:o:or10g3|OR10G3]]|0.414|
|[[:human genes:c:cactin|CACTIN]]|0.414|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.414|
|[[:human genes:a:arcn1|ARCN1]]|0.414|
|[[:human genes:p:psmc2|PSMC2]]|0.413|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.412|
|[[:human genes:m:mat2a|MAT2A]]|0.412|
|[[:human genes:p:psmd11|PSMD11]]|0.412|
|[[:human genes:p:psmc1|PSMC1]]|0.411|
|[[:human genes:r:rad21|RAD21]]|0.41|
|[[:human genes:d:ddt|DDT]]|0.41|
|[[:human genes:p:psmc5|PSMC5]]|0.409|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.409|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.409|
|[[:human genes:e:egr2|EGR2]]|0.409|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.409|
|[[:human genes:c:cbwd5|CBWD5]]|0.409|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.408|
|[[:human genes:r:rnpc3|RNPC3]]|0.408|
|[[:human genes:c:cdc6|CDC6]]|0.407|
|[[:human genes:z:znf655|ZNF655]]|0.407|
|[[:human genes:r:rrp7a|RRP7A]]|0.407|
|[[:human genes:n:npipb5|NPIPB5]]|0.407|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.406|
|[[:human genes:a:agap5|AGAP5]]|0.406|
|[[:human genes:c:cgb2|CGB2]]|0.406|
|[[:human genes:c:cbwd6|CBWD6]]|0.405|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.405|
|[[:human genes:n:ndc80|NDC80]]|0.405|
|[[:human genes:m:mcoln1|MCOLN1]]|0.405|
|[[:human genes:p:psma7|PSMA7]]|0.405|
|[[:human genes:u:upf1|UPF1]]|0.405|
|[[:human genes:p:psmc4|PSMC4]]|0.404|
|[[:human genes:s:syt9|SYT9]]|0.404|
|[[:human genes:p:pex5|PEX5]]|0.403|
|[[:human genes:p:plxnb3|PLXNB3]]|0.403|
|[[:human genes:c:ccdc116|CCDC116]]|0.403|
|[[:human genes:p:prpf19|PRPF19]]|0.403|
|[[:human genes:a:acd|ACD]]|0.402|
|[[:human genes:c:chmp4b|CHMP4B]]|0.402|
|[[:human genes:r:rpl9|RPL9]]|0.401|
|[[:human genes:k:kdm6a|KDM6A]]|0.401|
|[[:human genes:t:tsg101|TSG101]]|0.4|
|[[:human genes:m:mbtd1|MBTD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2107
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOCK6 Expression in NALM6 Cells: 2.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>