DOHH [The Human Chemical-Genetic Interaction Map Project]

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======= DOHH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOHH
  * **<color #00a2e8>Official Name</color>**: deoxyhypusine hydroxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83475|83475]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BU89|Q9BU89]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOHH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOHH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611262|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor. {ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000269|PubMed:16371467, ECO:0000269|PubMed:19706422}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deoxyhypusine monooxygenase activity|
|peptidyl-lysine modification to peptidyl-hypusine|
|cofactor binding|
|iron ion binding|
|protein maturation|
|peptidyl-lysine modification|
|cellular component|
|peptidyl-amino acid modification|
|oxidation-reduction process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.78|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.76|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.76|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.8|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.8|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.81|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.87|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.91|
|[[:results:exp539|42°C R08 exp539]]|1.93|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.94|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.95|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.97|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.99|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.06|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.08|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.09|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.1|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.16|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.17|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.23|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.25|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.3|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.35|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.35|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.4|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.43|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.43|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.49|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.54|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.54|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.55|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.6|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.78|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.86|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.89|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.93|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.99|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|3.15|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|3.18|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|3.25|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.34|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.51|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|4.69|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|4.77|
|[[:results:exp135|MS023 7μM R03 exp135]]|5.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rptor|RPTOR]]|0.756|
|[[:human genes:t:thg1l|THG1L]]|0.748|
|[[:human genes:b:bap1|BAP1]]|0.712|
|[[:human genes:n:nsd1|NSD1]]|0.687|
|[[:human genes:b:bak1|BAK1]]|0.686|
|[[:human genes:p:plaa|PLAA]]|0.665|
|[[:human genes:u:uap1|UAP1]]|0.663|
|[[:human genes:c:casp9|CASP9]]|0.656|
|[[:human genes:d:dpagt1|DPAGT1]]|0.656|
|[[:human genes:r:rnmt|RNMT]]|0.65|
|[[:human genes:g:gfpt1|GFPT1]]|0.649|
|[[:human genes:w:wdr24|WDR24]]|0.646|
|[[:human genes:t:triap1|TRIAP1]]|0.642|
|[[:human genes:r:rtcb|RTCB]]|0.636|
|[[:human genes:f:faf2|FAF2]]|0.633|
|[[:human genes:h:hccs|HCCS]]|0.632|
|[[:human genes:r:romo1|ROMO1]]|0.631|
|[[:human genes:a:apaf1|APAF1]]|0.629|
|[[:human genes:a:alg1|ALG1]]|0.628|
|[[:human genes:m:mtor|MTOR]]|0.624|
|[[:human genes:p:pmm2|PMM2]]|0.623|
|[[:human genes:m:mlst8|MLST8]]|0.622|
|[[:human genes:i:id3|ID3]]|0.621|
|[[:human genes:u:ube2g2|UBE2G2]]|0.611|
|[[:human genes:c:cbfb|CBFB]]|0.609|
|[[:human genes:a:atxn10|ATXN10]]|0.606|
|[[:human genes:p:ppcs|PPCS]]|0.604|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.6|
|[[:human genes:v:vdac2|VDAC2]]|0.597|
|[[:human genes:s:serf2|SERF2]]|0.594|
|[[:human genes:e:exoc4|EXOC4]]|0.592|
|[[:human genes:g:gmppb|GMPPB]]|0.592|
|[[:human genes:m:metap2|METAP2]]|0.59|
|[[:human genes:c:cycs|CYCS]]|0.588|
|[[:human genes:p:ppa2|PPA2]]|0.586|
|[[:human genes:d:dhps|DHPS]]|0.584|
|[[:human genes:t:trim28|TRIM28]]|0.582|
|[[:human genes:u:ubqln1|UBQLN1]]|0.581|
|[[:human genes:v:vezt|VEZT]]|0.578|
|[[:human genes:k:kdsr|KDSR]]|0.577|
|[[:human genes:v:vhl|VHL]]|0.575|
|[[:human genes:w:wdr59|WDR59]]|0.574|
|[[:human genes:c:ccdc101|CCDC101]]|0.572|
|[[:human genes:s:srp14|SRP14]]|0.564|
|[[:human genes:g:gnb1l|GNB1L]]|0.56|
|[[:human genes:t:trnt1|TRNT1]]|0.558|
|[[:human genes:m:march5|MARCH5]]|0.557|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.555|
|[[:human genes:t:taz|TAZ]]|0.553|
|[[:human genes:a:atp5j|ATP5J]]|0.552|
|[[:human genes:u:uhrf1|UHRF1]]|0.552|
|[[:human genes:s:slc25a26|SLC25A26]]|0.551|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.55|
|[[:human genes:a:alg2|ALG2]]|0.549|
|[[:human genes:s:ssbp2|SSBP2]]|0.547|
|[[:human genes:t:trmt10a|TRMT10A]]|0.547|
|[[:human genes:p:pdpk1|PDPK1]]|0.546|
|[[:human genes:d:dr1|DR1]]|0.544|
|[[:human genes:p:pelo|PELO]]|0.544|
|[[:human genes:a:atp5b|ATP5B]]|0.543|
|[[:human genes:e:elp3|ELP3]]|0.542|
|[[:human genes:o:opa1|OPA1]]|0.542|
|[[:human genes:l:lsm11|LSM11]]|0.541|
|[[:human genes:a:alg13|ALG13]]|0.54|
|[[:human genes:e:eny2|ENY2]]|0.539|
|[[:human genes:h:hspd1|HSPD1]]|0.537|
|[[:human genes:a:atp5d|ATP5D]]|0.536|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.535|
|[[:human genes:u:urm1|URM1]]|0.534|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.532|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.531|
|[[:human genes:m:med16|MED16]]|0.531|
|[[:human genes:a:atp5a1|ATP5A1]]|0.529|
|[[:human genes:z:zzz3|ZZZ3]]|0.529|
|[[:human genes:o:oraov1|ORAOV1]]|0.526|
|[[:human genes:a:atp5o|ATP5O]]|0.525|
|[[:human genes:l:lmo2|LMO2]]|0.523|
|[[:human genes:t:timm13|TIMM13]]|0.522|
|[[:human genes:a:alg5|ALG5]]|0.522|
|[[:human genes:u:ube2k|UBE2K]]|0.519|
|[[:human genes:r:rad23b|RAD23B]]|0.519|
|[[:human genes:r:rpp21|RPP21]]|0.518|
|[[:human genes:a:adsl|ADSL]]|0.517|
|[[:human genes:m:mllt1|MLLT1]]|0.516|
|[[:human genes:d:dnlz|DNLZ]]|0.516|
|[[:human genes:d:diablo|DIABLO]]|0.516|
|[[:human genes:r:rpe|RPE]]|0.514|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.514|
|[[:human genes:m:mfn1|MFN1]]|0.511|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.51|
|[[:human genes:l:lsm10|LSM10]]|0.51|
|[[:human genes:t:ten1|TEN1]]|0.51|
|[[:human genes:c:crls1|CRLS1]]|0.509|
|[[:human genes:z:znf592|ZNF592]]|0.508|
|[[:human genes:r:rpn1|RPN1]]|0.508|
|[[:human genes:a:atp2a2|ATP2A2]]|0.507|
|[[:human genes:t:tamm41|TAMM41]]|0.507|
|[[:human genes:d:dolk|DOLK]]|0.507|
|[[:human genes:u:utp23|UTP23]]|0.507|
|[[:human genes:s:ssb|SSB]]|0.505|
|[[:human genes:n:n6amt1|N6AMT1]]|0.502|
|[[:human genes:t:tsen54|TSEN54]]|0.499|
|[[:human genes:b:bcs1l|BCS1L]]|0.499|
|[[:human genes:t:ttc4|TTC4]]|0.499|
|[[:human genes:t:trmt61a|TRMT61A]]|0.498|
|[[:human genes:p:ppp6c|PPP6C]]|0.497|
|[[:human genes:e:elp2|ELP2]]|0.497|
|[[:human genes:v:vmp1|VMP1]]|0.49|
|[[:human genes:a:asxl2|ASXL2]]|0.49|
|[[:human genes:b:bptf|BPTF]]|0.49|
|[[:human genes:t:tbcb|TBCB]]|0.489|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.488|
|[[:human genes:p:ppp4c|PPP4C]]|0.487|
|[[:human genes:t:tufm|TUFM]]|0.487|
|[[:human genes:m:mbtps2|MBTPS2]]|0.486|
|[[:human genes:p:pdap1|PDAP1]]|0.486|
|[[:human genes:t:tbp|TBP]]|0.485|
|[[:human genes:c:cmtr1|CMTR1]]|0.485|
|[[:human genes:c:csnk2b|CSNK2B]]|0.485|
|[[:human genes:d:dhrsx|DHRSX]]|0.484|
|[[:human genes:m:med23|MED23]]|0.484|
|[[:human genes:f:fh|FH]]|0.483|
|[[:human genes:r:rpia|RPIA]]|0.482|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.482|
|[[:human genes:a:aars|AARS]]|0.48|
|[[:human genes:v:vps41|VPS41]]|0.478|
|[[:human genes:t:tmem41b|TMEM41B]]|0.476|
|[[:human genes:s:srrd|SRRD]]|0.476|
|[[:human genes:t:tti2|TTI2]]|0.476|
|[[:human genes:e:eif4e|EIF4E]]|0.475|
|[[:human genes:t:taf4|TAF4]]|0.474|
|[[:human genes:t:tti1|TTI1]]|0.473|
|[[:human genes:r:rft1|RFT1]]|0.473|
|[[:human genes:t:tbca|TBCA]]|0.472|
|[[:human genes:m:meaf6|MEAF6]]|0.472|
|[[:human genes:a:atic|ATIC]]|0.471|
|[[:human genes:a:atf7ip|ATF7IP]]|0.47|
|[[:human genes:s:srd5a3|SRD5A3]]|0.47|
|[[:human genes:g:gemin6|GEMIN6]]|0.469|
|[[:human genes:n:nae1|NAE1]]|0.469|
|[[:human genes:r:rabif|RABIF]]|0.468|
|[[:human genes:c:cd81|CD81]]|0.468|
|[[:human genes:g:gabpa|GABPA]]|0.467|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.467|
|[[:human genes:p:pam16|PAM16]]|0.466|
|[[:human genes:c:cept1|CEPT1]]|0.465|
|[[:human genes:m:mocs3|MOCS3]]|0.465|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.464|
|[[:human genes:f:fbxo11|FBXO11]]|0.461|
|[[:human genes:t:trmt5|TRMT5]]|0.461|
|[[:human genes:z:zfx|ZFX]]|0.46|
|[[:human genes:a:atp5l|ATP5L]]|0.46|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.457|
|[[:human genes:z:zrsr2|ZRSR2]]|0.457|
|[[:human genes:p:pgs1|PGS1]]|0.457|
|[[:human genes:e:eif1ax|EIF1AX]]|0.456|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.455|
|[[:human genes:y:yars2|YARS2]]|0.455|
|[[:human genes:s:sec63|SEC63]]|0.454|
|[[:human genes:o:osgep|OSGEP]]|0.454|
|[[:human genes:t:tsen34|TSEN34]]|0.453|
|[[:human genes:h:haus8|HAUS8]]|0.452|
|[[:human genes:a:alg6|ALG6]]|0.45|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.45|
|[[:human genes:p:polr3h|POLR3H]]|0.45|
|[[:human genes:p:pdcd5|PDCD5]]|0.449|
|[[:human genes:m:maml1|MAML1]]|0.448|
|[[:human genes:e:elf2|ELF2]]|0.448|
|[[:human genes:m:mios|MIOS]]|0.447|
|[[:human genes:t:tmem242|TMEM242]]|0.446|
|[[:human genes:e:eif3f|EIF3F]]|0.445|
|[[:human genes:a:atp5i|ATP5I]]|0.445|
|[[:human genes:b:brpf1|BRPF1]]|0.445|
|[[:human genes:d:dpf2|DPF2]]|0.443|
|[[:human genes:l:ldb1|LDB1]]|0.443|
|[[:human genes:d:ddost|DDOST]]|0.443|
|[[:human genes:e:eef1e1|EEF1E1]]|0.443|
|[[:human genes:t:thoc6|THOC6]]|0.442|
|[[:human genes:e:exoc3|EXOC3]]|0.442|
|[[:human genes:s:sec62|SEC62]]|0.44|
|[[:human genes:e:eno1|ENO1]]|0.44|
|[[:human genes:f:fech|FECH]]|0.44|
|[[:human genes:g:gemin8|GEMIN8]]|0.439|
|[[:human genes:s:slc4a7|SLC4A7]]|0.437|
|[[:human genes:d:ddx20|DDX20]]|0.436|
|[[:human genes:m:mrps14|MRPS14]]|0.436|
|[[:human genes:d:ddx1|DDX1]]|0.436|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.435|
|[[:human genes:u:ube2m|UBE2M]]|0.434|
|[[:human genes:t:tkt|TKT]]|0.434|
|[[:human genes:e:eprs|EPRS]]|0.432|
|[[:human genes:m:mapk14|MAPK14]]|0.432|
|[[:human genes:c:chchd4|CHCHD4]]|0.431|
|[[:human genes:s:slc25a19|SLC25A19]]|0.431|
|[[:human genes:f:fnta|FNTA]]|0.43|
|[[:human genes:d:ddx39a|DDX39A]]|0.43|
|[[:human genes:d:dars2|DARS2]]|0.428|
|[[:human genes:a:ago2|AGO2]]|0.428|
|[[:human genes:v:vrk1|VRK1]]|0.428|
|[[:human genes:m:mrpl21|MRPL21]]|0.428|
|[[:human genes:w:wdr82|WDR82]]|0.427|
|[[:human genes:a:atad1|ATAD1]]|0.426|
|[[:human genes:b:brwd1|BRWD1]]|0.426|
|[[:human genes:c:ctc1|CTC1]]|0.426|
|[[:human genes:p:prkrir|PRKRIR]]|0.425|
|[[:human genes:s:sec61g|SEC61G]]|0.425|
|[[:human genes:m:mrpl23|MRPL23]]|0.424|
|[[:human genes:d:dap3|DAP3]]|0.424|
|[[:human genes:d:dad1|DAD1]]|0.424|
|[[:human genes:r:rnf214|RNF214]]|0.423|
|[[:human genes:u:uba5|UBA5]]|0.423|
|[[:human genes:t:taf11|TAF11]]|0.423|
|[[:human genes:c:cbx3|CBX3]]|0.42|
|[[:human genes:k:kctd5|KCTD5]]|0.42|
|[[:human genes:s:sox7|SOX7]]|0.42|
|[[:human genes:g:gemin7|GEMIN7]]|0.42|
|[[:human genes:p:pik3r4|PIK3R4]]|0.419|
|[[:human genes:u:uba3|UBA3]]|0.418|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.418|
|[[:human genes:c:crcp|CRCP]]|0.418|
|[[:human genes:s:sdha|SDHA]]|0.418|
|[[:human genes:t:tle4|TLE4]]|0.418|
|[[:human genes:u:uxt|UXT]]|0.418|
|[[:human genes:s:sars2|SARS2]]|0.418|
|[[:human genes:t:telo2|TELO2]]|0.417|
|[[:human genes:a:alg14|ALG14]]|0.417|
|[[:human genes:a:atp5h|ATP5H]]|0.417|
|[[:human genes:e:elp6|ELP6]]|0.416|
|[[:human genes:c:c21orf59|C21orf59]]|0.415|
|[[:human genes:s:snapc5|SNAPC5]]|0.415|
|[[:human genes:e:elac2|ELAC2]]|0.415|
|[[:human genes:p:pgm3|PGM3]]|0.415|
|[[:human genes:p:phb|PHB]]|0.414|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.414|
|[[:human genes:c:c15orf41|C15orf41]]|0.414|
|[[:human genes:h:hars|HARS]]|0.414|
|[[:human genes:p:ppp5c|PPP5C]]|0.413|
|[[:human genes:l:lsmd1|LSMD1]]|0.412|
|[[:human genes:b:brd9|BRD9]]|0.412|
|[[:human genes:o:oip5|OIP5]]|0.411|
|[[:human genes:r:runx1|RUNX1]]|0.411|
|[[:human genes:g:gtf3a|GTF3A]]|0.411|
|[[:human genes:s:stau1|STAU1]]|0.411|
|[[:human genes:r:rbmx2|RBMX2]]|0.41|
|[[:human genes:t:trip12|TRIP12]]|0.409|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.408|
|[[:human genes:p:pfn1|PFN1]]|0.408|
|[[:human genes:u:ube2l3|UBE2L3]]|0.408|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.408|
|[[:human genes:p:ppcdc|PPCDC]]|0.406|
|[[:human genes:c:cox7b|COX7B]]|0.406|
|[[:human genes:a:arl14ep|ARL14EP]]|0.406|
|[[:human genes:s:srp72|SRP72]]|0.406|
|[[:human genes:u:uqcr10|UQCR10]]|0.405|
|[[:human genes:t:txnl4b|TXNL4B]]|0.405|
|[[:human genes:m:mbtps1|MBTPS1]]|0.404|
|[[:human genes:u:ube3a|UBE3A]]|0.404|
|[[:human genes:d:dnajc3|DNAJC3]]|0.404|
|[[:human genes:m:mrps34|MRPS34]]|0.404|
|[[:human genes:p:ptdss1|PTDSS1]]|0.404|
|[[:human genes:x:xpo6|XPO6]]|0.403|
|[[:human genes:c:cep57|CEP57]]|0.403|
|[[:human genes:c:cct7|CCT7]]|0.403|
|[[:human genes:c:cdipt|CDIPT]]|0.403|
|[[:human genes:t:tefm|TEFM]]|0.402|
|[[:human genes:m:mrps5|MRPS5]]|0.402|
|[[:human genes:r:rpusd4|RPUSD4]]|0.402|
|[[:human genes:f:flcn|FLCN]]|0.401|
|[[:human genes:c:c17orf89|C17orf89]]|0.401|
|[[:human genes:y:yars|YARS]]|0.401|
|[[:human genes:t:timm22|TIMM22]]|0.401|
|[[:human genes:c:cul3|CUL3]]|0.4|
|[[:human genes:a:atp5c1|ATP5C1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 115/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|4/28|
|bone|5/26|
|breast|4/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|1/21|
|liver|4/20|
|lung|12/75|
|lymphocyte|3/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|3/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 447
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOHH Expression in NALM6 Cells: 4.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>