DPM1 [The Human Chemical-Genetic Interaction Map Project]

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======= DPM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPM1
  * **<color #00a2e8>Official Name</color>**: dolichyl-phosphate mannosyltransferase subunit 1, catalytic
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8813|8813]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60762|O60762]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603503|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycos transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl-phosphate beta-D-mannosyltransferase activity|
|dolichol-phosphate-mannose synthase complex|
|dolichol metabolic process|
|polyprenol metabolic process|
|dolichyl-phosphate-mannose-protein mannosyltransferase activity|
|protein O-linked mannosylation|
|protein mannosylation|
|GPI anchor biosynthetic process|
|GPI anchor metabolic process|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|mannosylation|
|glycolipid biosynthetic process|
|protein N-linked glycosylation|
|protein lipidation|
|lipoprotein biosynthetic process|
|phosphatidylinositol biosynthetic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|protein O-linked glycosylation|
|lipoprotein metabolic process|
|membrane lipid biosynthetic process|
|isoprenoid metabolic process|
|phosphatidylinositol metabolic process|
|membrane lipid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|glycoprotein biosynthetic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|glycoprotein metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.15|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.13|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.08|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.72|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.7|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.74|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.75|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.84|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.86|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.87|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.91|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.91|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.92|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.04|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.18|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.27|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.31|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.4|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg9|ALG9]]|0.53|
|[[:human genes:d:dpm3|DPM3]]|0.53|
|[[:human genes:s:sec62|SEC62]]|0.503|
|[[:human genes:m:mpdu1|MPDU1]]|0.49|
|[[:human genes:d:dhrsx|DHRSX]]|0.465|
|[[:human genes:s:sec63|SEC63]]|0.46|
|[[:human genes:a:alg6|ALG6]]|0.441|
|[[:human genes:m:manf|MANF]]|0.438|
|[[:human genes:d:dnajb11|DNAJB11]]|0.436|
|[[:human genes:a:alg8|ALG8]]|0.434|
|[[:human genes:a:alg3|ALG3]]|0.425|
|[[:human genes:a:atg9a|ATG9A]]|0.413|
|[[:human genes:p:prkcsh|PRKCSH]]|0.408|
|[[:human genes:s:stt3a|STT3A]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|2/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3305
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPM1 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>