DR1 [The Human Chemical-Genetic Interaction Map Project]

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======= DR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DR1
  * **<color #00a2e8>Official Name</color>**: down-regulator of transcription 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1810|1810]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01658|Q01658]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601482|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:8670811}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBFD NFYB HMF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative cofactor 2 complex|
|core promoter binding|
|regulation of RNA polymerase II transcriptional preinitiation complex assembly|
|Ada2/Gcn5/Ada3 transcription activator complex|
|TBP-class protein binding|
|regulation of transcription initiation from RNA polymerase II promoter|
|regulation of DNA-templated transcription, initiation|
|histone H3 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|chromatin remodeling|
|protein acylation|
|transcription corepressor activity|
|transcription coactivator activity|
|peptidyl-lysine modification|
|transcription factor binding|
|histone modification|
|covalent chromatin modification|
|regulation of protein complex assembly|
|protein heterodimerization activity|
|chromatin organization|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|regulation of cellular component biogenesis|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.93|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.79|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.79|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.72|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.74|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.8|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.81|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.81|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.92|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.95|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.05|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.15|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.3|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.672|
|[[:human genes:r:rptor|RPTOR]]|0.565|
|[[:human genes:t:tsen54|TSEN54]]|0.554|
|[[:human genes:o:oraov1|ORAOV1]]|0.551|
|[[:human genes:a:atxn10|ATXN10]]|0.548|
|[[:human genes:d:dohh|DOHH]]|0.544|
|[[:human genes:a:alg1|ALG1]]|0.543|
|[[:human genes:r:rpp21|RPP21]]|0.531|
|[[:human genes:p:ppp6c|PPP6C]]|0.531|
|[[:human genes:u:uap1|UAP1]]|0.522|
|[[:human genes:a:adsl|ADSL]]|0.522|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.518|
|[[:human genes:s:srp14|SRP14]]|0.511|
|[[:human genes:m:med16|MED16]]|0.509|
|[[:human genes:g:gmppb|GMPPB]]|0.509|
|[[:human genes:a:atic|ATIC]]|0.503|
|[[:human genes:r:rtcb|RTCB]]|0.5|
|[[:human genes:w:wdr24|WDR24]]|0.497|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.494|
|[[:human genes:b:btaf1|BTAF1]]|0.493|
|[[:human genes:n:nae1|NAE1]]|0.493|
|[[:human genes:d:dpagt1|DPAGT1]]|0.493|
|[[:human genes:v:vhl|VHL]]|0.491|
|[[:human genes:p:pmm2|PMM2]]|0.49|
|[[:human genes:r:rnmt|RNMT]]|0.486|
|[[:human genes:g:gfpt1|GFPT1]]|0.486|
|[[:human genes:t:ten1|TEN1]]|0.485|
|[[:human genes:c:c15orf41|C15orf41]]|0.484|
|[[:human genes:g:gemin7|GEMIN7]]|0.483|
|[[:human genes:t:trmt61a|TRMT61A]]|0.476|
|[[:human genes:f:fh|FH]]|0.473|
|[[:human genes:g:gnb1l|GNB1L]]|0.473|
|[[:human genes:g:gemin8|GEMIN8]]|0.471|
|[[:human genes:b:bap1|BAP1]]|0.47|
|[[:human genes:p:ppcs|PPCS]]|0.469|
|[[:human genes:a:alg13|ALG13]]|0.467|
|[[:human genes:g:gemin6|GEMIN6]]|0.466|
|[[:human genes:v:vezt|VEZT]]|0.464|
|[[:human genes:e:exoc4|EXOC4]]|0.464|
|[[:human genes:p:pelo|PELO]]|0.463|
|[[:human genes:t:trnt1|TRNT1]]|0.462|
|[[:human genes:u:urm1|URM1]]|0.462|
|[[:human genes:t:tti2|TTI2]]|0.461|
|[[:human genes:s:ssb|SSB]]|0.459|
|[[:human genes:e:elp3|ELP3]]|0.458|
|[[:human genes:b:bak1|BAK1]]|0.458|
|[[:human genes:u:uhrf1|UHRF1]]|0.457|
|[[:human genes:r:rpia|RPIA]]|0.457|
|[[:human genes:t:triap1|TRIAP1]]|0.457|
|[[:human genes:t:tbcb|TBCB]]|0.455|
|[[:human genes:u:ube2m|UBE2M]]|0.454|
|[[:human genes:u:uba3|UBA3]]|0.454|
|[[:human genes:t:ttc4|TTC4]]|0.452|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.45|
|[[:human genes:s:slc25a19|SLC25A19]]|0.448|
|[[:human genes:t:tpk1|TPK1]]|0.446|
|[[:human genes:e:eny2|ENY2]]|0.445|
|[[:human genes:t:trim28|TRIM28]]|0.444|
|[[:human genes:w:wdr59|WDR59]]|0.444|
|[[:human genes:f:fbxo11|FBXO11]]|0.441|
|[[:human genes:d:ddx1|DDX1]]|0.44|
|[[:human genes:l:lsm10|LSM10]]|0.44|
|[[:human genes:o:oip5|OIP5]]|0.438|
|[[:human genes:s:slc25a26|SLC25A26]]|0.438|
|[[:human genes:t:tsen34|TSEN34]]|0.438|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.437|
|[[:human genes:s:snapc5|SNAPC5]]|0.437|
|[[:human genes:h:haus8|HAUS8]]|0.436|
|[[:human genes:n:n6amt1|N6AMT1]]|0.436|
|[[:human genes:r:rabggtb|RABGGTB]]|0.435|
|[[:human genes:r:rfk|RFK]]|0.432|
|[[:human genes:m:mocs3|MOCS3]]|0.432|
|[[:human genes:k:kctd5|KCTD5]]|0.432|
|[[:human genes:m:msto1|MSTO1]]|0.43|
|[[:human genes:k:kdsr|KDSR]]|0.427|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.427|
|[[:human genes:m:med4|MED4]]|0.425|
|[[:human genes:t:txnrd1|TXNRD1]]|0.425|
|[[:human genes:u:ube2g2|UBE2G2]]|0.425|
|[[:human genes:a:atp5j|ATP5J]]|0.424|
|[[:human genes:d:dhps|DHPS]]|0.424|
|[[:human genes:p:ptar1|PTAR1]]|0.423|
|[[:human genes:t:tti1|TTI1]]|0.423|
|[[:human genes:d:dolk|DOLK]]|0.422|
|[[:human genes:a:atp5b|ATP5B]]|0.422|
|[[:human genes:n:nsd1|NSD1]]|0.421|
|[[:human genes:p:plaa|PLAA]]|0.42|
|[[:human genes:w:wdr92|WDR92]]|0.42|
|[[:human genes:h:hccs|HCCS]]|0.419|
|[[:human genes:c:casp9|CASP9]]|0.419|
|[[:human genes:u:uxt|UXT]]|0.419|
|[[:human genes:r:rft1|RFT1]]|0.418|
|[[:human genes:z:zzz3|ZZZ3]]|0.417|
|[[:human genes:a:alg2|ALG2]]|0.416|
|[[:human genes:t:telo2|TELO2]]|0.416|
|[[:human genes:l:lsm11|LSM11]]|0.416|
|[[:human genes:h:hspd1|HSPD1]]|0.415|
|[[:human genes:e:eef1e1|EEF1E1]]|0.415|
|[[:human genes:d:ddx55|DDX55]]|0.415|
|[[:human genes:w:wdr1|WDR1]]|0.415|
|[[:human genes:d:drap1|DRAP1]]|0.412|
|[[:human genes:r:romo1|ROMO1]]|0.412|
|[[:human genes:c:ctc1|CTC1]]|0.411|
|[[:human genes:m:med23|MED23]]|0.409|
|[[:human genes:e:eif4e|EIF4E]]|0.408|
|[[:human genes:d:ddost|DDOST]]|0.408|
|[[:human genes:m:mtor|MTOR]]|0.408|
|[[:human genes:i:id3|ID3]]|0.408|
|[[:human genes:m:mllt1|MLLT1]]|0.406|
|[[:human genes:t:trip12|TRIP12]]|0.404|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.404|
|[[:human genes:p:polr3h|POLR3H]]|0.403|
|[[:human genes:g:gtf3a|GTF3A]]|0.402|
|[[:human genes:e:elp2|ELP2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 159/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|7/28|
|bone|4/25|
|breast|4/33|
|central nervous system|13/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|3/15|
|kidney|4/21|
|liver|3/20|
|lung|16/75|
|lymphocyte|3/14|
|ovary|6/26|
|pancreas|8/24|
|peripheral nervous system|1/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|13/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2385
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DR1 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>