DRD5 [The Human Chemical-Genetic Interaction Map Project]

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======= DRD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DRD5
  * **<color #00a2e8>Official Name</color>**: dopamine receptor D5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1816|1816]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21918|P21918]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DRD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DRD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126453|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. {ECO:0000269|PubMed:1834671}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dopamine neurotransmitter receptor activity, coupled via Gs|
|sensitization|
|negative regulation of NAD(P)H oxidase activity|
|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|
|dopamine neurotransmitter receptor activity|
|regulation of systemic arterial blood pressure by vasopressin|
|positive regulation of blood pressure by epinephrine-norepinephrine|
|nonassociative learning|
|phospholipase C-activating dopamine receptor signaling pathway|
|regulation of female receptivity|
|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|
|positive regulation of adenylate cyclase activity|
|female mating behavior|
|adenylate cyclase-activating dopamine receptor signaling pathway|
|regulation of NAD(P)H oxidase activity|
|dopamine binding|
|long-term synaptic depression|
|synaptic transmission, dopaminergic|
|mating behavior|
|positive regulation of cyclase activity|
|positive regulation of lyase activity|
|negative regulation of oxidoreductase activity|
|G-protein alpha-subunit binding|
|regulation of adenylate cyclase activity|
|reproductive behavior|
|vasoconstriction|
|non-motile cilium|
|response to amphetamine|
|mating|
|dopamine receptor signaling pathway|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of blood pressure|
|activation of adenylate cyclase activity|
|negative regulation of blood vessel diameter|
|regulation of cyclase activity|
|regulation of lyase activity|
|negative regulation of blood pressure|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|response to amine|
|endocrine process|
|response to bronchodilator|
|brush border membrane|
|ciliary membrane|
|transmission of nerve impulse|
|response to cocaine|
|negative regulation of synaptic transmission|
|associative learning|
|response to anesthetic|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|regulation of systemic arterial blood pressure|
|regulation of oxidoreductase activity|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|response to alkaloid|
|reactive oxygen species metabolic process|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|multicellular organismal signaling|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|learning|
|cAMP-mediated signaling|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|response to ammonium ion|
|regulation of synaptic plasticity|
|cilium|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|learning or memory|
|cognition|
|response to xenobiotic stimulus|
|second-messenger-mediated signaling|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|regulation of anatomical structure size|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|response to wounding|
|behavior|
|cellular response to organonitrogen compound|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|cellular homeostasis|
|response to organic cyclic compound|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of molecular function|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.91|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.86|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.74|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.71|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4202
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DRD5 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>