DYNC1H1 [The Human Chemical-Genetic Interaction Map Project]

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======= DYNC1H1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DYNC1H1
  * **<color #00a2e8>Official Name</color>**: dynein cytoplasmic 1 heavy chain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1778|1778]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14204|Q14204]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DYNC1H1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DYNC1H1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074). {ECO:0000269|PubMed:27462074}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA 5|
|Dynein heavy|
|AAA 9|
|MT|
|AAA 6|
|AAA 8|
|AAA 7|
|DHC N1|
|DHC N2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|minus-end-directed vesicle transport along microtubule|
|minus-end-directed organelle transport along microtubule|
|positive regulation of spindle assembly|
|regulation of metaphase plate congression|
|cytoplasmic mRNA processing body assembly|
|stress granule assembly|
|retrograde axonal transport|
|ATP-dependent microtubule motor activity, minus-end-directed|
|cytoplasmic dynein complex|
|nuclear migration|
|dynein complex|
|dynein light chain binding|
|nucleus localization|
|dynein intermediate chain binding|
|regulation of spindle assembly|
|dynein light intermediate chain binding|
|regulation of mitotic spindle organization|
|regulation of spindle organization|
|establishment of spindle localization|
|vesicle transport along microtubule|
|spindle localization|
|vesicle cytoskeletal trafficking|
|cytoplasmic microtubule|
|cytoplasmic microtubule organization|
|axonal transport|
|axon cytoplasm|
|axo-dendritic transport|
|filopodium|
|positive regulation of organelle assembly|
|mitotic spindle organization|
|organelle transport along microtubule|
|azurophil granule lumen|
|ciliary basal body-plasma membrane docking|
|positive regulation of cold-induced thermogenesis|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|cell cortex|
|regulation of cold-induced thermogenesis|
|spindle organization|
|transport along microtubule|
|organelle localization by membrane tethering|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|membrane docking|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|regulation of microtubule cytoskeleton organization|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|positive regulation of intracellular transport|
|regulation of cell cycle G2/M phase transition|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|positive regulation of cytoskeleton organization|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mitotic cell cycle phase transition|
|microtubule-based movement|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|microtubule|
|cilium assembly|
|regulation of intracellular transport|
|establishment of organelle localization|
|cilium organization|
|Golgi vesicle transport|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|ribonucleoprotein complex biogenesis|
|supramolecular fiber organization|
|cell projection assembly|
|microtubule cytoskeleton organization|
|neutrophil degranulation|
|centrosome|
|neutrophil activation involved in immune response|
|cell division|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|regulation of cytoskeleton organization|
|organelle localization|
|myeloid leukocyte activation|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulated exocytosis|
|regulation of cell cycle process|
|organelle assembly|
|leukocyte mediated immunity|
|exocytosis|
|cellular protein-containing complex assembly|
|regulation of cellular localization|
|leukocyte activation|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|cell cycle process|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|positive regulation of multicellular organismal process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.3|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.24|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.19|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.14|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.89|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.89|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.81|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.71|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.7|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.78|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.81|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.88|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.9|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.95|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.95|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.98|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.04|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.21|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.35|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.54|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.64|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.79|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.9|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|5.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 728/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 481
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DYNC1H1 Expression in NALM6 Cells: 10.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>