DYNC1LI1 [The Human Chemical-Genetic Interaction Map Project]

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======= DYNC1LI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DYNC1LI1
  * **<color #00a2e8>Official Name</color>**: dynein cytoplasmic 1 light intermediate chain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51143|51143]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6G9|Q9Y6G9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DYNC1LI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DYNC1LI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. {ECO:0000269|PubMed:19229290}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DLIC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitotic cell cycle spindle assembly checkpoint|
|positive regulation of spindle checkpoint|
|positive regulation of cell cycle checkpoint|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|dynein heavy chain binding|
|regulation of spindle checkpoint|
|regulation of mitotic spindle checkpoint|
|cytoplasmic dynein complex|
|regulation of cell cycle checkpoint|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|ficolin-1-rich granule membrane|
|regulation of chromosome separation|
|microtubule motor activity|
|regulation of mitotic sister chromatid segregation|
|GDP binding|
|regulation of sister chromatid segregation|
|kinetochore|
|condensed chromosome kinetochore|
|secretory granule membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|regulation of chromosome segregation|
|spindle pole|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|regulation of nuclear division|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|microtubule-based movement|
|positive regulation of cell cycle process|
|microtubule|
|regulation of chromosome organization|
|Golgi vesicle transport|
|positive regulation of cell cycle|
|GTP binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|neutrophil degranulation|
|centrosome|
|neutrophil activation involved in immune response|
|cell division|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|microtubule-based process|
|viral process|
|regulated exocytosis|
|regulation of cell cycle process|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|cytoskeleton organization|
|secretion|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|establishment of localization in cell|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.02|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.02|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.87|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.86|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.82|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.76|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.76|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.73|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.72|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.71|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.82|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.99|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2259
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DYNC1LI1 Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>