DYRK3 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= DYRK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DYRK3
  * **<color #00a2e8>Official Name</color>**: dual specificity tyrosine phosphorylation regulated kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8444|8444]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43781|O43781]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DYRK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DYRK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603497|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). May act by regulating CREB/CRE signaling (By similarity). Stabilizes and prevents stress granule disassembly thereby regulating mTORC1 signaling during cellular stress. During stressful conditions, DYRK3 partitions to the stress granule from the cytosol, as well as mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol, and promotes the phosphorylation of the mTORC1 inhibitor, AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (PubMed:20167603). {ECO:0000250|UniProtKB:Q922Y0, ECO:0000269|PubMed:10779429, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear speck organization|
|stress granule disassembly|
|ribonucleoprotein complex disassembly|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|nuclear body organization|
|pericentriolar material|
|protein serine/threonine/tyrosine kinase activity|
|positive regulation of cell cycle G2/M phase transition|
|negative regulation of signal transduction by p53 class mediator|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|regulation of TORC1 signaling|
|organelle disassembly|
|cytoplasmic stress granule|
|negative regulation of response to DNA damage stimulus|
|erythrocyte differentiation|
|peptidyl-threonine phosphorylation|
|protein tyrosine kinase activity|
|erythrocyte homeostasis|
|peptidyl-threonine modification|
|positive regulation of cell cycle phase transition|
|regulation of TOR signaling|
|myeloid cell homeostasis|
|nucleus organization|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|peptidyl-serine phosphorylation|
|regulation of signal transduction by p53 class mediator|
|peptidyl-serine modification|
|homeostasis of number of cells|
|regulation of cell cycle G2/M phase transition|
|magnesium ion binding|
|regulation of response to DNA damage stimulus|
|myeloid cell differentiation|
|protein kinase activity|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|positive regulation of cell cycle process|
|protein serine/threonine kinase activity|
|cytoskeleton|
|positive regulation of cell cycle|
|cellular component disassembly|
|nuclear speck|
|regulation of cell cycle phase transition|
|cell division|
|negative regulation of intracellular signal transduction|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|intracellular membrane-bounded organelle|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|protein phosphorylation|
|negative regulation of cell death|
|regulation of cell cycle|
|negative regulation of signal transduction|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of cell death|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16045
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DYRK3 Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>