E2F1 [The Human Chemical-Genetic Interaction Map Project]

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======= E2F1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: E2F1
  * **<color #00a2e8>Official Name</color>**: E2F transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1869|1869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01094|Q01094]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=E2F1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20E2F1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189971|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.  This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). {ECO:0000250|UniProtKB:Q61501, ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:17704056, ECO:0000269|PubMed:20040599, ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:8170954}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E2F TDP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rb-E2F complex|
|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|
|lens fiber cell apoptotic process|
|negative regulation of fat cell proliferation|
|regulation of fat cell proliferation|
|anoikis|
|positive regulation of glial cell proliferation|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|epithelial cell apoptotic process|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|regulation of glial cell proliferation|
|proximal promoter sequence-specific DNA binding|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|negative regulation of G0 to G1 transition|
|mRNA stabilization|
|regulation of G0 to G1 transition|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|negative regulation of fat cell differentiation|
|RNA stabilization|
|cellular response to nerve growth factor stimulus|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of fibroblast proliferation|
|response to nerve growth factor|
|negative regulation of mRNA catabolic process|
|negative regulation of DNA binding|
|cellular response to fatty acid|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|positive regulation of establishment of protein localization to mitochondrion|
|negative regulation of RNA catabolic process|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|positive regulation of gliogenesis|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|RNA polymerase II transcription factor complex|
|signal transduction involved in DNA damage checkpoint|
|regulation of mitochondrial membrane permeability|
|signal transduction involved in DNA integrity checkpoint|
|regulation of establishment of protein localization to mitochondrion|
|signal transduction involved in cell cycle checkpoint|
|negative regulation of mRNA metabolic process|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|regulation of fibroblast proliferation|
|regulation of membrane permeability|
|response to fatty acid|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|positive regulation of mitochondrion organization|
|regulation of gliogenesis|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|signal transduction by p53 class mediator|
|regulation of fat cell differentiation|
|positive regulation of protein localization to membrane|
|regulation of DNA binding|
|mitochondrial membrane organization|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|intrinsic apoptotic signaling pathway|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|protein dimerization activity|
|regulation of cell cycle G1/S phase transition|
|negative regulation of binding|
|positive regulation of apoptotic signaling pathway|
|regulation of mRNA stability|
|regulation of mitochondrion organization|
|regulation of RNA stability|
|cellular response to xenobiotic stimulus|
|cellular response to hypoxia|
|regulation of protein localization to membrane|
|cell cycle checkpoint|
|cellular response to decreased oxygen levels|
|regulation of mRNA catabolic process|
|cellular response to acid chemical|
|negative regulation of mitotic cell cycle phase transition|
|mitochondrial transport|
|cellular response to oxygen levels|
|negative regulation of cell cycle phase transition|
|nuclear chromatin|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|negative regulation of cellular catabolic process|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|response to xenobiotic stimulus|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|transcription factor binding|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|positive regulation of cell cycle|
|regulation of binding|
|response to oxygen levels|
|forebrain development|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|sequence-specific DNA binding|
|mitochondrion organization|
|regulation of cell cycle phase transition|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|positive regulation of neurogenesis|
|centrosome|
|cellular response to growth factor stimulus|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|spermatogenesis|
|male gamete generation|
|negative regulation of cell cycle|
|protein-containing complex|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|gamete generation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|brain development|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|head development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|membrane organization|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|central nervous system development|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of catabolic process|
|cell cycle process|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.98|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.78|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.8|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.85|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.91|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.11|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.21|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfdp1|TFDP1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16567
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='E2F1 Expression in NALM6 Cells: 7.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>