ECEL1 [The Human Chemical-Genetic Interaction Map Project]

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======= ECEL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ECEL1
  * **<color #00a2e8>Official Name</color>**: endothelin converting enzyme like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9427|9427]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95672|O95672]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ECEL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ECEL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605896|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M13 N|
|Peptidase M13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory system process|
|respiratory gaseous exchange by respiratory system|
|metallopeptidase activity|
|metalloendopeptidase activity|
|neuropeptide signaling pathway|
|proteolysis|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.86|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.7|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.74|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3639
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ECEL1 Expression in NALM6 Cells: -4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>