ECHS1 [The Human Chemical-Genetic Interaction Map Project]

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======= ECHS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ECHS1
  * **<color #00a2e8>Official Name</color>**: enoyl-CoA hydratase, short chain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1892|1892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30084|P30084]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ECHS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ECHS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602292|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate. {ECO:0000269|PubMed:26251176}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ECH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enoyl-CoA hydratase activity|
|fatty acid beta-oxidation|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid catabolic process|
|monocarboxylic acid catabolic process|
|cellular lipid catabolic process|
|lipid modification|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|fatty acid metabolic process|
|mitochondrial matrix|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.23|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.05|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.04|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.85|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.77|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.85|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.1|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.13|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.95|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|3.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8927
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ECHS1 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>