ECSCR [The Human Chemical-Genetic Interaction Map Project]

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======= ECSCR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ECSCR
  * **<color #00a2e8>Official Name</color>**: endothelial cell surface expressed chemotaxis and apoptosis regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=641700|641700]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q19T08|Q19T08]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ECSCR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ECSCR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615736|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endothelial cell apoptotic process|
|positive regulation of epithelial cell apoptotic process|
|regulation of endothelial cell apoptotic process|
|regulation of epithelial cell apoptotic process|
|negative regulation of angiogenesis|
|positive regulation of proteasomal protein catabolic process|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of proteasomal protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of cellular protein catabolic process|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|blood vessel morphogenesis|
|positive regulation of catabolic process|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|chemotaxis|
|taxis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|negative regulation of developmental process|
|regulation of catabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|negative regulation of multicellular organismal process|
|locomotion|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12383
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ECSCR Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>