EDF1 [The Human Chemical-Genetic Interaction Map Project]

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======= EDF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDF1
  * **<color #00a2e8>Official Name</color>**: endothelial differentiation related factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8721|8721]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60869|O60869]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605107|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HTH 3|
|MBF1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TFIID-class transcription factor complex binding|
|positive regulation of DNA binding|
|endothelial cell differentiation|
|intracellular|
|endothelium development|
|regulation of DNA binding|
|positive regulation of binding|
|calmodulin binding|
|transcription coactivator activity|
|regulation of binding|
|regulation of lipid metabolic process|
|epithelial cell differentiation|
|nucleolus|
|epithelium development|
|RNA binding|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-3.37|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.87|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.81|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.42|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.24|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.13|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.06|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.98|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.97|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.94|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.89|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.89|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.86|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.86|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.85|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.85|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.82|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.8|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.75|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.74|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.7|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.7|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11153
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDF1 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>