EDN1 [The Human Chemical-Genetic Interaction Map Project]

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======= EDN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDN1
  * **<color #00a2e8>Official Name</color>**: endothelin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1906|1906]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05305|P05305]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endothelins are endothelium-derived vasoconstrictor peptides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Endothelin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase C deactivation|
|endothelin A receptor binding|
|rhythmic excitation|
|phospholipase D-activating G protein-coupled receptor signaling pathway|
|response to prostaglandin F|
|endothelin B receptor binding|
|nitric oxide transport|
|regulation of prostaglandin-endoperoxide synthase activity|
|positive regulation of chemokine-mediated signaling pathway|
|positive regulation of prostaglandin-endoperoxide synthase activity|
|rough endoplasmic reticulum lumen|
|rhythmic synaptic transmission|
|response to ozone|
|negative regulation of nitric-oxide synthase biosynthetic process|
|positive regulation of sarcomere organization|
|vein smooth muscle contraction|
|Weibel-Palade body|
|cellular response to mineralocorticoid stimulus|
|regulation of systemic arterial blood pressure by endothelin|
|histamine secretion|
|maternal process involved in parturition|
|negative regulation of smooth muscle cell apoptotic process|
|regulation of sarcomere organization|
|positive regulation of cell growth involved in cardiac muscle cell development|
|histamine transport|
|epithelial fluid transport|
|regulation of chemokine-mediated signaling pathway|
|artery smooth muscle contraction|
|positive regulation of prostaglandin secretion|
|positive regulation of cell size|
|positive regulation of odontogenesis|
|regulation of prostaglandin secretion|
|tonic smooth muscle contraction|
|positive regulation of receptor biosynthetic process|
|positive regulation of renal sodium excretion|
|basal part of cell|
|positive regulation of urine volume|
|superoxide anion generation|
|parturition|
|vascular smooth muscle contraction|
|positive regulation of icosanoid secretion|
|transepithelial transport|
|regulation of cell growth involved in cardiac muscle cell development|
|phasic smooth muscle contraction|
|response to muscle stretch|
|positive regulation of fatty acid transport|
|azole transport|
|regulation of icosanoid secretion|
|regulation of nitric-oxide synthase biosynthetic process|
|prostanoid biosynthetic process|
|response to salt|
|prostaglandin biosynthetic process|
|positive regulation of cardiac muscle cell differentiation|
|middle ear morphogenesis|
|regulation of renal sodium excretion|
|regulation of urine volume|
|response to leptin|
|regulation of receptor biosynthetic process|
|positive regulation of neutrophil chemotaxis|
|positive regulation of heart rate|
|inositol phosphate-mediated signaling|
|regulation of smooth muscle cell apoptotic process|
|regulation of excretion|
|positive regulation of granulocyte chemotaxis|
|regulation of odontogenesis|
|regulation of fatty acid transport|
|fluid transport|
|positive regulation of cardiocyte differentiation|
|branching involved in blood vessel morphogenesis|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|response to prostaglandin|
|positive regulation of smooth muscle contraction|
|positive regulation of muscle hypertrophy|
|vasoconstriction|
|response to mineralocorticoid|
|positive regulation of cardiac muscle tissue growth|
|positive regulation of vascular smooth muscle cell proliferation|
|phosphatidylinositol 3-kinase signaling|
|prostanoid metabolic process|
|prostaglandin metabolic process|
|positive regulation of organic acid transport|
|multicellular organism aging|
|regulation of renal system process|
|regulation of neutrophil migration|
|regulation of cardiac muscle cell differentiation|
|negative regulation of muscle cell apoptotic process|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of heart growth|
|positive regulation of heart contraction|
|response to testosterone|
|superoxide metabolic process|
|negative regulation of blood vessel diameter|
|regulation of sensory perception of pain|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|regulation of sensory perception|
|response to dexamethasone|
|respiratory gaseous exchange by respiratory system|
|regulation of granulocyte chemotaxis|
|unsaturated fatty acid biosynthetic process|
|positive regulation of cardiac muscle tissue development|
|positive regulation of muscle contraction|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|icosanoid biosynthetic process|
|positive regulation of organ growth|
|endocrine process|
|response to nicotine|
|regulation of vascular smooth muscle cell proliferation|
|negative regulation of blood coagulation|
|positive regulation of anion transport|
|regulation of cardiocyte differentiation|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of cytokine-mediated signaling pathway|
|negative regulation of hemostasis|
|membrane depolarization|
|smooth muscle contraction|
|negative regulation of coagulation|
|ammonium transport|
|positive regulation of mitotic nuclear division|
|positive regulation of oxidoreductase activity|
|cellular response to fatty acid|
|regulation of nitric oxide biosynthetic process|
|regulation of cardiac muscle hypertrophy|
|cellular response to glucocorticoid stimulus|
|positive regulation of response to cytokine stimulus|
|regulation of vasoconstriction|
|regulation of organic acid transport|
|peptide hormone secretion|
|regulation of cardiac muscle tissue growth|
|positive regulation of striated muscle cell differentiation|
|regulation of muscle hypertrophy|
|cellular response to corticosteroid stimulus|
|regulation of smooth muscle contraction|
|positive regulation of lipid transport|
|negative regulation of hormone secretion|
|regulation of heart growth|
|response to activity|
|positive regulation of nuclear division|
|regulation of muscle cell apoptotic process|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of blood circulation|
|positive regulation of muscle tissue development|
|phosphatidylinositol-mediated signaling|
|negative regulation of wound healing|
|hormone secretion|
|positive regulation of JUN kinase activity|
|regulation of glucose transmembrane transport|
|body fluid secretion|
|positive regulation of organelle assembly|
|sensory perception of pain|
|inositol lipid-mediated signaling|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of cardiac muscle tissue development|
|neural crest cell development|
|regulation of blood coagulation|
|regulation of hemostasis|
|positive regulation of lipid localization|
|dorsal/ventral pattern formation|
|positive regulation of animal organ morphogenesis|
|hormone transport|
|regulation of coagulation|
|neutrophil chemotaxis|
|stem cell development|
|mesenchymal cell development|
|cellular response to calcium ion|
|response to fatty acid|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|negative regulation of response to wounding|
|regulation of muscle adaptation|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of muscle cell differentiation|
|regulation of JUN kinase activity|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|regulation of actomyosin structure organization|
|neural crest cell differentiation|
|fatty acid derivative biosynthetic process|
|transport vesicle|
|neutrophil migration|
|regulation of systemic arterial blood pressure|
|regulation of organ growth|
|response to antineoplastic agent|
|regulation of anion transport|
|positive regulation of reactive oxygen species metabolic process|
|regulation of oxidoreductase activity|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of heart rate|
|hormone activity|
|regulation of pH|
|positive regulation of endothelial cell migration|
|granulocyte migration|
|regulation of striated muscle cell differentiation|
|unsaturated fatty acid metabolic process|
|regulation of lipid transport|
|regulation of NIK/NF-kappaB signaling|
|renal system process|
|icosanoid metabolic process|
|reactive oxygen species metabolic process|
|regulation of leukocyte chemotaxis|
|response to amino acid|
|ear morphogenesis|
|fatty acid biosynthetic process|
|positive regulation of hormone secretion|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|branching morphogenesis of an epithelial tube|
|regulation of striated muscle tissue development|
|regulation of smooth muscle cell proliferation|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of chemotaxis|
|regulation of nervous system process|
|regulation of wound healing|
|regulation of lipid localization|
|positive regulation of JNK cascade|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|monovalent inorganic cation homeostasis|
|positive regulation of epithelial cell migration|
|regulation of G protein-coupled receptor signaling pathway|
|response to glucocorticoid|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|drug transport|
|positive regulation of mitotic cell cycle|
|response to calcium ion|
|regulation of muscle cell differentiation|
|cellular response to transforming growth factor beta stimulus|
|mesenchymal cell differentiation|
|regulation of endothelial cell migration|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|regulation of muscle contraction|
|response to corticosteroid|
|response to transforming growth factor beta|
|cellular response to interferon-gamma|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of cell growth|
|fatty acid derivative metabolic process|
|regulation of response to wounding|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of mitotic nuclear division|
|morphogenesis of a branching structure|
|signal release|
|vascular process in circulatory system|
|positive regulation of developmental growth|
|cartilage development|
|peptide secretion|
|cytokine activity|
|cellular response to interleukin-1|
|regulation of response to cytokine stimulus|
|neurotransmitter transport|
|regulation of reactive oxygen species metabolic process|
|response to interferon-gamma|
|regulation of blood pressure|
|regulation of cell size|
|regulation of JNK cascade|
|monocarboxylic acid biosynthetic process|
|cellular response to hypoxia|
|cellular response to steroid hormone stimulus|
|cellular response to metal ion|
|regulation of nuclear division|
|response to ketone|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|positive regulation of supramolecular fiber organization|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|negative regulation of secretion by cell|
|cellular response to acid chemical|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cell chemotaxis|
|multi-multicellular organism process|
|regulation of chemotaxis|
|response to mechanical stimulus|
|cellular response to oxygen levels|
|positive regulation of cytoskeleton organization|
|regulation of epithelial cell migration|
|cellular response to inorganic substance|
|regulation of organelle assembly|
|mesenchyme development|
|ear development|
|connective tissue development|
|negative regulation of secretion|
|regulation of stress-activated MAPK cascade|
|regulation of muscle system process|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to tumor necrosis factor|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|muscle contraction|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|positive regulation of ion transport|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of cell cycle process|
|regulation of blood circulation|
|embryonic organ morphogenesis|
|muscle system process|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|response to antibiotic|
|organic acid biosynthetic process|
|epithelial tube morphogenesis|
|response to lipopolysaccharide|
|angiogenesis|
|fatty acid metabolic process|
|response to molecule of bacterial origin|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|response to steroid hormone|
|regulation of developmental growth|
|regionalization|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to hypoxia|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|regulation of supramolecular fiber organization|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|response to metal ion|
|regulation of cellular component size|
|positive regulation of cell cycle|
|in utero embryonic development|
|leukocyte migration|
|response to oxygen levels|
|response to oxidative stress|
|regulation of actin filament-based process|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|positive regulation of secretion by cell|
|cellular response to drug|
|blood vessel morphogenesis|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|regulation of membrane potential|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of secretion|
|pattern specification process|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|negative regulation of transport|
|blood vessel development|
|divalent inorganic cation homeostasis|
|skeletal system development|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|response to toxic substance|
|vasculature development|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|heart development|
|monocarboxylic acid metabolic process|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|regulation of system process|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|metal ion homeostasis|
|regulation of mitotic cell cycle|
|cellular cation homeostasis|
|chordate embryonic development|
|cellular ion homeostasis|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of growth|
|response to bacterium|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|innate immune response|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|multicellular organismal reproductive process|
|cation transport|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|regulation of cell development|
|defense response to other organism|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|multi-organism reproductive process|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.05|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.73|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18420
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDN1 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>