EDNRB [The Human Chemical-Genetic Interaction Map Project]

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======= EDNRB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDNRB
  * **<color #00a2e8>Official Name</color>**: endothelin receptor type B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1910|1910]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24530|P24530]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDNRB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDNRB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131244|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enteric smooth muscle cell differentiation|
|response to endothelin|
|endothelin receptor activity|
|posterior midgut development|
|endothelin receptor signaling pathway|
|negative regulation of neuron maturation|
|vein smooth muscle contraction|
|positive regulation of penile erection|
|type 1 angiotensin receptor binding|
|regulation of penile erection|
|negative regulation of cell maturation|
|regulation of fever generation|
|epithelial fluid transport|
|regulation of neuron maturation|
|enteric nervous system development|
|regulation of heat generation|
|midgut development|
|macrophage chemotaxis|
|positive regulation of renal sodium excretion|
|positive regulation of urine volume|
|vascular smooth muscle contraction|
|transepithelial transport|
|phasic smooth muscle contraction|
|negative regulation of adenylate cyclase activity|
|macrophage migration|
|negative regulation of cyclase activity|
|melanocyte differentiation|
|regulation of renal sodium excretion|
|regulation of urine volume|
|negative regulation of lyase activity|
|regulation of cell maturation|
|regulation of excretion|
|cGMP-mediated signaling|
|fluid transport|
|regulation of adenylate cyclase activity|
|response to pain|
|vasodilation|
|vasoconstriction|
|pigment cell differentiation|
|smooth muscle cell differentiation|
|regulation of renal system process|
|negative regulation of blood vessel diameter|
|regulation of sensory perception of pain|
|peptide hormone binding|
|regulation of sensory perception|
|developmental pigmentation|
|regulation of cyclase activity|
|regulation of acute inflammatory response|
|regulation of lyase activity|
|autonomic nervous system development|
|smooth muscle contraction|
|neural crest cell migration|
|positive regulation of blood vessel diameter|
|multicellular organismal response to stress|
|peripheral nervous system development|
|sensory perception of pain|
|positive regulation of reproductive process|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|pigmentation|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of pH|
|renal system process|
|myeloid leukocyte migration|
|digestive tract development|
|regulation of nervous system process|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|monovalent inorganic cation homeostasis|
|regulation of tube size|
|digestive system development|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of reproductive process|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|ameboidal-type cell migration|
|regulation of blood pressure|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|cell chemotaxis|
|cellular response to biotic stimulus|
|mesenchyme development|
|negative regulation of neuron differentiation|
|membrane raft|
|nuclear membrane|
|muscle cell differentiation|
|muscle contraction|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|negative regulation of neurogenesis|
|muscle system process|
|negative regulation of nervous system development|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|leukocyte migration|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|muscle structure development|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|cellular response to lipid|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|response to bacterium|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of defense response|
|regulation of multi-organism process|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|regulation of neurogenesis|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|sensory perception|
|positive regulation of transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.33|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.71|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.72|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11798
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDNRB Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>