EFNB3 [The Human Chemical-Genetic Interaction Map Project]

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======= EFNB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EFNB3
  * **<color #00a2e8>Official Name</color>**: ephrin B3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1949|1949]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15768|Q15768]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EFNB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EFNB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602297|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ephrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|
|axon choice point recognition|
|trans-synaptic signaling by trans-synaptic complex|
|trans-synaptic signaling, modulating synaptic transmission|
|transmembrane-ephrin receptor activity|
|ephrin receptor binding|
|adult walking behavior|
|walking behavior|
|hippocampal mossy fiber to CA3 synapse|
|neuron recognition|
|integral component of postsynaptic density membrane|
|T cell costimulation|
|lymphocyte costimulation|
|integral component of presynaptic membrane|
|negative regulation of axonogenesis|
|virus receptor activity|
|adult locomotory behavior|
|ephrin receptor signaling pathway|
|viral entry into host cell|
|negative regulation of cell morphogenesis involved in differentiation|
|entry into host cell|
|entry into host|
|adult behavior|
|negative regulation of neuron projection development|
|interaction with host|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|locomotory behavior|
|viral life cycle|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|negative regulation of neuron differentiation|
|cell recognition|
|positive regulation of cell-cell adhesion|
|axon guidance|
|neuron projection guidance|
|negative regulation of neurogenesis|
|regulation of leukocyte cell-cell adhesion|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|regulation of T cell activation|
|negative regulation of cell development|
|glutamatergic synapse|
|positive regulation of lymphocyte activation|
|axonogenesis|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|axon development|
|positive regulation of cell activation|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|behavior|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|symbiotic process|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.8|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.71|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.73|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4867
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EFNB3 Expression in NALM6 Cells: -2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>