EFTUD2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= EFTUD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EFTUD2
  * **<color #00a2e8>Official Name</color>**: elongation factor Tu GTP binding domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9343|9343]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15029|Q15029]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EFTUD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EFTUD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603892|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EFG IV|
|GTP EFTU|
|EFG C|
|GTP EFTU D2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U5 snRNA binding|
|U2-type catalytic step 2 spliceosome|
|U4/U6 x U5 tri-snRNP complex|
|U2-type precatalytic spliceosome|
|Cajal body|
|response to cocaine|
|response to anesthetic|
|catalytic step 2 spliceosome|
|response to alkaloid|
|ribonucleoprotein complex|
|response to ammonium ion|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|response to xenobiotic stimulus|
|GTPase activity|
|GTP binding|
|RNA splicing|
|nuclear speck|
|cellular response to drug|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|RNA binding|
|response to oxygen-containing compound|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.95|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.86|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.8|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.77|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.77|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.74|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.78|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.78|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:utp3|UTP3]]|0.468|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.454|
|[[:human genes:t:tsg101|TSG101]]|0.429|
|[[:human genes:r:rpl35|RPL35]]|0.418|
|[[:human genes:g:golga8k|GOLGA8K]]|0.415|
|[[:human genes:n:nfatc4|NFATC4]]|0.41|
|[[:human genes:r:rrp7a|RRP7A]]|0.409|
|[[:human genes:p:pola1|POLA1]]|0.402|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 637/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|24/28|
|bone|21/26|
|breast|32/33|
|central nervous system|48/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|13/21|
|liver|13/20|
|lung|61/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|21/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 311
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EFTUD2 Expression in NALM6 Cells: 7.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>