EGF [The Human Chemical-Genetic Interaction Map Project]

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======= EGF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EGF
  * **<color #00a2e8>Official Name</color>**: epidermal growth factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1950|1950]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01133|P01133]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EGF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EGF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941). {ECO:0000269|PubMed:10964941, ECO:0000269|PubMed:17671655}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|Ldl recept b|
|EGF 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of hyaluronan biosynthetic process|
|negative regulation of cholesterol efflux|
|transmembrane receptor protein tyrosine kinase activator activity|
|regulation of protein localization to early endosome|
|positive regulation of cerebellar granule cell precursor proliferation|
|positive regulation of protein localization to early endosome|
|regulation of hyaluronan biosynthetic process|
|positive regulation of epidermal growth factor-activated receptor activity|
|regulation of cerebellar granule cell precursor proliferation|
|positive regulation of protein localization to endosome|
|regulation of protein localization to endosome|
|negative regulation of cholesterol transport|
|negative regulation of sterol transport|
|activation of transmembrane receptor protein tyrosine kinase activity|
|Ras guanyl-nucleotide exchange factor activity|
|mammary gland lobule development|
|Wnt-activated receptor activity|
|mammary gland alveolus development|
|regulation of cholesterol efflux|
|positive regulation of receptor internalization|
|negative regulation of lipid transport|
|regulation of epidermal growth factor-activated receptor activity|
|ERK1 and ERK2 cascade|
|positive regulation of peptidyl-threonine phosphorylation|
|positive regulation of epidermal growth factor receptor signaling pathway|
|ERBB2 signaling pathway|
|positive regulation of ERBB signaling pathway|
|epidermal growth factor receptor binding|
|positive regulation of signaling receptor activity|
|regulation of polysaccharide biosynthetic process|
|Wnt-protein binding|
|regulation of protein localization to cell surface|
|regulation of calcium ion import|
|negative regulation of lipid localization|
|negative regulation of Notch signaling pathway|
|regulation of polysaccharide metabolic process|
|regulation of peptidyl-threonine phosphorylation|
|regulation of cholesterol transport|
|regulation of sterol transport|
|negative regulation of epidermal growth factor receptor signaling pathway|
|epidermal growth factor receptor signaling pathway|
|negative regulation of ERBB signaling pathway|
|positive regulation of neural precursor cell proliferation|
|positive regulation of receptor-mediated endocytosis|
|clathrin-coated vesicle membrane|
|activation of MAPKK activity|
|positive regulation of mitotic nuclear division|
|regulation of receptor internalization|
|positive regulation of protein tyrosine kinase activity|
|positive regulation of DNA binding|
|positive regulation of nuclear division|
|platelet alpha granule lumen|
|ERBB signaling pathway|
|positive regulation of carbohydrate metabolic process|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of neural precursor cell proliferation|
|regulation of protein tyrosine kinase activity|
|canonical Wnt signaling pathway|
|regulation of ERBB signaling pathway|
|regulation of carbohydrate biosynthetic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|regulation of Notch signaling pathway|
|regulation of lipid transport|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of DNA binding|
|mammary gland development|
|platelet degranulation|
|regulation of receptor signaling pathway via JAK-STAT|
|branching morphogenesis of an epithelial tube|
|regulation of receptor signaling pathway via STAT|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|positive regulation of cellular protein catabolic process|
|positive regulation of canonical Wnt signaling pathway|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|positive regulation of mitotic cell cycle|
|regulation of ubiquitin-dependent protein catabolic process|
|activation of MAPK activity|
|morphogenesis of a branching epithelium|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of mitotic nuclear division|
|morphogenesis of a branching structure|
|regulation of signaling receptor activity|
|positive regulation of Wnt signaling pathway|
|positive regulation of binding|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of nuclear division|
|regulation of carbohydrate metabolic process|
|receptor complex|
|regulation of endocytosis|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein kinase B signaling|
|negative regulation of secretion|
|regulation of cellular protein catabolic process|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of MAP kinase activity|
|regulation of canonical Wnt signaling pathway|
|positive regulation of cell cycle process|
|lysosomal membrane|
|epithelial tube morphogenesis|
|angiogenesis|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|positive regulation of cell cycle|
|regulation of binding|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|signal transduction by protein phosphorylation|
|blood vessel morphogenesis|
|gland development|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|morphogenesis of an epithelium|
|negative regulation of transport|
|blood vessel development|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|tissue morphogenesis|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of ion transport|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|regulation of proteolysis|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|tube development|
|regulation of cell migration|
|membrane organization|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|regulation of nervous system development|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|epithelium development|
|cell-cell signaling|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14005
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EGF Expression in NALM6 Cells: -1.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>