EGFR [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= EGFR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EGFR
  * **<color #00a2e8>Official Name</color>**: epidermal growth factor receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1956|1956]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00533|P00533]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EGFR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EGFR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131550|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Recep L domain|
|Furin-like|
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|multivesicular body, internal vesicle lumen|
|epidermal growth factor-activated receptor activity|
|activation of phospholipase A2 activity by calcium-mediated signaling|
|Shc-EGFR complex|
|positive regulation of prolactin secretion|
|response to cobalamin|
|activation of phospholipase A2 activity|
|epidermal growth factor binding|
|response to hydroxyisoflavone|
|positive regulation of nitric oxide mediated signal transduction|
|response to phenylpropanoid|
|positive regulation of protein kinase C activity|
|regulation of protein kinase C activity|
|positive regulation of phospholipase A2 activity|
|response to UV-A|
|nitric-oxide synthase regulator activity|
|positive regulation of production of miRNAs involved in gene silencing by miRNA|
|regulation of nitric oxide mediated signal transduction|
|regulation of phospholipase A2 activity|
|magnesium ion homeostasis|
|midgut development|
|eyelid development in camera-type eye|
|morphogenesis of an epithelial fold|
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|MAP kinase kinase kinase activity|
|regulation of production of miRNAs involved in gene silencing by miRNA|
|positive regulation of superoxide anion generation|
|astrocyte activation|
|tongue development|
|regulation of production of small RNA involved in gene silencing by RNA|
|negative regulation of cardiocyte differentiation|
|regulation of superoxide anion generation|
|positive regulation of gene silencing by miRNA|
|positive regulation of posttranscriptional gene silencing|
|salivary gland morphogenesis|
|liver regeneration|
|cellular response to dexamethasone stimulus|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of tissue remodeling|
|activation of phospholipase C activity|
|positive regulation of vasoconstriction|
|ERBB2 signaling pathway|
|salivary gland development|
|positive regulation of synaptic transmission, glutamatergic|
|peptidyl-tyrosine autophosphorylation|
|regulation of superoxide metabolic process|
|basal plasma membrane|
|positive regulation of cyclin-dependent protein kinase activity|
|astrocyte development|
|positive regulation of DNA replication|
|positive regulation of G1/S transition of mitotic cell cycle|
|cellular response to estradiol stimulus|
|protein insertion into membrane|
|cellular response to cadmium ion|
|hydrogen peroxide metabolic process|
|glial cell activation|
|regulation of bone resorption|
|response to dexamethasone|
|neuroinflammatory response|
|negative regulation of Notch signaling pathway|
|cerebral cortex cell migration|
|positive regulation of phospholipase C activity|
|cellular response to epidermal growth factor stimulus|
|exocrine system development|
|regulation of nitric-oxide synthase activity|
|negative regulation of epidermal growth factor receptor signaling pathway|
|regulation of phospholipase C activity|
|positive regulation of cell cycle G1/S phase transition|
|response to epidermal growth factor|
|digestive tract morphogenesis|
|regulation of bone remodeling|
|regulation of cardiocyte differentiation|
|epidermal growth factor receptor signaling pathway|
|positive regulation of fibroblast proliferation|
|negative regulation of ERBB signaling pathway|
|astrocyte differentiation|
|clathrin-coated vesicle membrane|
|activation of MAPKK activity|
|regulation of monooxygenase activity|
|transmembrane receptor protein tyrosine kinase activity|
|positive regulation of protein localization to plasma membrane|
|cellular response to glucocorticoid stimulus|
|regulation of vasoconstriction|
|positive regulation of blood vessel diameter|
|telencephalon cell migration|
|endocytic vesicle|
|cellular response to corticosteroid stimulus|
|positive regulation of phospholipase activity|
|forebrain cell migration|
|positive regulation of protein localization to cell periphery|
|response to cadmium ion|
|positive regulation of DNA repair|
|ovulation cycle|
|regulation of synaptic transmission, glutamatergic|
|cellular response to amino acid stimulus|
|positive regulation of blood circulation|
|ERBB signaling pathway|
|hair follicle development|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|regulation of tissue remodeling|
|animal organ regeneration|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|virus receptor activity|
|response to osmotic stress|
|positive regulation of NIK/NF-kappaB signaling|
|positive regulation of mitotic cell cycle phase transition|
|cellular response to mechanical stimulus|
|regulation of fibroblast proliferation|
|regulation of epidermal growth factor receptor signaling pathway|
|protein phosphatase binding|
|positive regulation of smooth muscle cell proliferation|
|embryonic placenta development|
|response to vitamin|
|regulation of gene silencing by miRNA|
|protein tyrosine kinase activity|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|regulation of ERBB signaling pathway|
|cellular response to ketone|
|molting cycle|
|hair cycle|
|positive regulation of cell cycle phase transition|
|response to antineoplastic agent|
|viral entry into host cell|
|regulation of protein localization to plasma membrane|
|regulation of oxidoreductase activity|
|positive regulation of reactive oxygen species metabolic process|
|positive regulation of peptide hormone secretion|
|regulation of lipase activity|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of response to DNA damage stimulus|
|gland morphogenesis|
|regulation of cyclin-dependent protein kinase activity|
|double-stranded DNA binding|
|entry into host cell|
|entry into host|
|regulation of Notch signaling pathway|
|antibiotic metabolic process|
|positive regulation of peptidyl-serine phosphorylation|
|glial cell development|
|regulation of DNA replication|
|diterpenoid metabolic process|
|regulation of NIK/NF-kappaB signaling|
|reactive oxygen species metabolic process|
|response to amino acid|
|regulation of protein localization to cell periphery|
|cerebral cortex development|
|regulation of phosphatidylinositol 3-kinase signaling|
|terpenoid metabolic process|
|positive regulation of protein localization to membrane|
|regulation of DNA repair|
|liver development|
|positive regulation of hormone secretion|
|regulation of gene silencing|
|hepaticobiliary system development|
|integrin binding|
|digestive tract development|
|cellular response to reactive oxygen species|
|negative regulation of protein catabolic process|
|regulation of smooth muscle cell proliferation|
|response to estradiol|
|regulation of peptidyl-serine phosphorylation|
|transmembrane signaling receptor activity|
|isoprenoid metabolic process|
|positive regulation of inflammatory response|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|circadian rhythm|
|digestive system development|
|response to UV|
|positive regulation of canonical Wnt signaling pathway|
|peptidyl-tyrosine phosphorylation|
|response to glucocorticoid|
|calcium-mediated signaling|
|peptidyl-tyrosine modification|
|regulation of G1/S transition of mitotic cell cycle|
|response to calcium ion|
|positive regulation of synaptic transmission|
|positive regulation of mitotic cell cycle|
|placenta development|
|early endosome membrane|
|regeneration|
|interaction with host|
|response to corticosteroid|
|positive regulation of cell growth|
|positive regulation of protein kinase B signaling|
|regulation of cell cycle G1/S phase transition|
|lung development|
|vascular process in circulatory system|
|glial cell differentiation|
|respiratory tube development|
|pallium development|
|positive regulation of Wnt signaling pathway|
|regulation of reactive oxygen species metabolic process|
|regulation of JNK cascade|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|regulation of protein localization to membrane|
|positive regulation of epithelial cell proliferation|
|cellular response to metal ion|
|positive regulation of DNA metabolic process|
|protein autophosphorylation|
|response to ketone|
|response to reactive oxygen species|
|respiratory system development|
|basolateral plasma membrane|
|viral life cycle|
|calmodulin binding|
|actin filament binding|
|receptor complex|
|cellular response to acid chemical|
|regulation of peptide hormone secretion|
|positive regulation of ERK1 and ERK2 cascade|
|endosome membrane|
|response to mechanical stimulus|
|gliogenesis|
|response to nutrient|
|regulation of response to DNA damage stimulus|
|regulation of protein kinase B signaling|
|cellular response to inorganic substance|
|membrane raft|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear membrane|
|cellular response to oxidative stress|
|regulation of peptidyl-tyrosine phosphorylation|
|telencephalon development|
|learning or memory|
|positive regulation of growth|
|positive regulation of MAP kinase activity|
|ossification|
|establishment of protein localization to membrane|
|regulation of hormone secretion|
|synapse|
|positive regulation of protein secretion|
|endosome|
|rhythmic process|
|regulation of canonical Wnt signaling pathway|
|positive regulation of cell cycle process|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|ubiquitin protein ligase binding|
|cognition|
|response to xenobiotic stimulus|
|negative regulation of mitotic cell cycle|
|response to light stimulus|
|cadherin binding|
|negative regulation of catabolic process|
|camera-type eye development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|apical plasma membrane|
|positive regulation of cellular protein localization|
|response to steroid hormone|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to acid chemical|
|enzyme binding|
|regulation of DNA metabolic process|
|eye development|
|visual system development|
|regulation of Wnt signaling pathway|
|sensory system development|
|response to metal ion|
|MAPK cascade|
|positive regulation of cell cycle|
|in utero embryonic development|
|translation|
|skin development|
|regulation of protein catabolic process|
|response to oxidative stress|
|forebrain development|
|blood circulation|
|signal transduction by protein phosphorylation|
|chromatin binding|
|circulatory system process|
|cellular response to drug|
|positive regulation of secretion by cell|
|peptide biosynthetic process|
|gland development|
|regulation of mitotic cell cycle phase transition|
|epidermis development|
|focal adhesion|
|regulation of cell growth|
|reproductive structure development|
|positive regulation of protein transport|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of secretion|
|cofactor metabolic process|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of cell cycle phase transition|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|positive regulation of defense response|
|wound healing|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|response to nutrient levels|
|inflammatory response|
|cellular response to growth factor stimulus|
|drug metabolic process|
|positive regulation of cell migration|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|positive regulation of cell motility|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|sensory organ development|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|behavior|
|response to wounding|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|regulation of system process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|cell surface|
|Golgi membrane|
|metal ion homeostasis|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|perinuclear region of cytoplasm|
|viral process|
|cation homeostasis|
|regulation of protein transport|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of defense response|
|positive regulation of hydrolase activity|
|head development|
|symbiotic process|
|ion homeostasis|
|cellular amide metabolic process|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|membrane organization|
|response to lipid|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|cell migration|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.79|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.93|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.95|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11250
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EGFR Expression in NALM6 Cells: -1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>