EIF1 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10209|10209]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41567|P41567]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619901|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SUI1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit binding|
|eukaryotic 43S preinitiation complex|
|dosage compensation by inactivation of X chromosome|
|dosage compensation|
|translation factor activity, RNA binding|
|translation initiation factor activity|
|regulation of translational initiation|
|translational initiation|
|regulation of gene expression, epigenetic|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.71|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.11|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.1|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.03|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.91|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.83|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.82|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.7|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.7|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.91|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.93|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.94|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.02|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.02|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.09|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.13|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mbtps2|MBTPS2]]|0.476|
|[[:human genes:p:pdap1|PDAP1]]|0.462|
|[[:human genes:c:cbfb|CBFB]]|0.44|
|[[:human genes:d:dnajc3|DNAJC3]]|0.416|
|[[:human genes:a:alg5|ALG5]]|0.409|
|[[:human genes:t:trmt10a|TRMT10A]]|0.408|
|[[:human genes:e:eif1ax|EIF1AX]]|0.406|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.405|
|[[:human genes:l:ldb1|LDB1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 120/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|4/26|
|breast|10/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|7/21|
|liver|4/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|8/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1877
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF1 Expression in NALM6 Cells: 8.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>