EIF2B1 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF2B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2B1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2B subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1967|1967]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14232|Q14232]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606686|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IF-2B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 2B complex|
|oligodendrocyte development|
|translation initiation factor activity|
|oligodendrocyte differentiation|
|regulation of translational initiation|
|guanyl-nucleotide exchange factor activity|
|glial cell development|
|response to heat|
|response to glucose|
|translational initiation|
|response to hexose|
|response to monosaccharide|
|glial cell differentiation|
|response to carbohydrate|
|T cell receptor signaling pathway|
|response to temperature stimulus|
|gliogenesis|
|antigen receptor-mediated signaling pathway|
|regulation of translation|
|translation|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|immune response-activating cell surface receptor signaling pathway|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|activation of immune response|
|cellular amide metabolic process|
|positive regulation of immune response|
|response to hormone|
|central nervous system development|
|response to organonitrogen compound|
|identical protein binding|
|response to nitrogen compound|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.73|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 314/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|5/28|
|bone|8/26|
|breast|18/33|
|central nervous system|30/56|
|cervix|3/4|
|colorectal|8/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|10/21|
|liver|9/20|
|lung|35/75|
|lymphocyte|7/16|
|ovary|12/26|
|pancreas|8/24|
|peripheral nervous system|3/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|10/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 456
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2B1 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>